VEGF-D 蛋白, Human (HEK293)

VEGF-D Protein, Human (HEK293) is a regulator of both angiogenesis and lymphangiogenesis.

VEGF-D 是一种强大的淋巴管生成和血管生成生长因子，也是小鼠乳糜微粒代谢的主要调节因子^[1]。血管内皮生长因子D（VEGF-D）在淋巴管生成和血管生成中具有重要功能。高血浆 VEGF-D 水平与心力衰竭的发生率相关。VEGF-D 与心房颤动 (AF) 和中风的关系尚不清楚，我们假设 VEGF-D 也可能与 AF 和缺血性中风的发生率相关^[2]。

The ED₅₀ is <1 μg/mL as measured by HUVEC cells.

Human

CHO

Tag Free

O43915 (F89-R205)

2277  [NCBI]

FAATFYDIETLKVIDEEWQRTQCSPRETCVEVASELGKSTNTFFKPPCVNVFRCGGCCNEESLICMNTSTSYISKQLFEISVPLTSVPELVPVKVANHTGCKCLPTAPRHPYSIIRR

Homodimer. 18-19 kDa on SDS-PAGE under reducing conditions

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against PBS.

<0.2 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Tirronen A, et al. Deletion of Lymphangiogenic and Angiogenic Growth Factor VEGF-D Leads to Severe Hyperlipidemia and Delayed Clearance of Chylomicron Remnants. 2018 Oct;38(10):2327-2337.  [Content Brief]

  [2]. Berntsson J1, et al. Increased vascular endothelial growth factor D is associated with atrial fibrillation and ischaemic stroke. Heart. 2018 Oct 16. pii: heartjnl-2018-313684.  [Content Brief]