Wnt4 蛋白, Human (HEK293, C-hFc)

The Wnt4 protein is a Frizzled receptor ligand that plays a critical role in embryonic urogenital tract and lung development. It is critical for embryonic kidney development and the formation of early renal vesicles and the mesenchymal to epithelial transition. Wnt4 protein, Human (HEK293, C-hFc) is the recombinant human-derived Wnt4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Wnt4 protein, Human (HEK293, C-hFc) is 329 a.a., with molecular weight of 65.6 kDa.

Wnt4 蛋白作为七跨膜受体卷曲家族成员的配体，在泌尿生殖道和肺部的胚胎发育中发挥着至关重要的作用。它是胚胎肾脏发育过程中正常间充质到上皮细胞的转变以及早期上皮肾囊泡形成所必需的。Wnt4对于女性苗勒氏管的形成和卵巢中正常卵母细胞水平的维持是不可或缺的。此外，卵巢中 3β-羟基类固醇脱氢酶的正常下调也是必要的。此外，Wnt4 对于正常的肺部发育和气管软骨环的正确形成至关重要。该蛋白与 PORCN 和 PKD1 相互作用，强调了它在各种发育过程和信号通路中的复杂参与。

Human

HEK293

C-hFc

P56705 (S23-R351)

54361  [NCBI]

SNWLYLAKLSSVGSISEEETCEKLKGLIQRQVQMCKRNLEVMDSVRRGAQLAIEECQYQFRNRRWNCSTLDSLPVFGKVVTQGTREAAFVYAISSAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTCNKTSKAIDGCELLCCGRGFHTAQVELAERCSCKFHWCCFVKCRQCQRLVELHTCR

65.6 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized a 0.22 μm filtered solution of Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.