2. 一站式药筛
  3. 化合物库
  4. MCE CNS BBB类药化合物库
MCE CNS BBB类药化合物库 - MCE CNS BBB Lead-like Library

Cat. No.: HY-L919

随着人口老龄化和竞争压力的增加，中枢神经系统退行性疾病已变成现代社会严重的医学问题，例如帕金森病、阿尔兹海默症、脑肿瘤和多发性硬化。然而中枢药物研发成功率却很低，这主要与血脑屏障（blood-brain barrier, BBB）有关。 血脑屏障（BBB）是包围中枢神经系统（CNS）微血管系统的半透性屏障结构。在毛细血管中，紧密排列的内皮细胞排列在血管内部，形成广泛的紧密连接。该屏障与一系列受体、转运蛋白、外排泵和其他细胞成分一起，控制着血管内分子进入和排出大脑。完整的血脑屏障不仅能够阻止大多数血液中的物质流入大脑，还能将大分子药物的通过率限制在近乎为零，同时屏蔽超过 98% 的小分子药物，从而为中枢神经系统营造稳定的内环境。 与非中枢神经系统药物相比，氢键、脂溶性和分子大小等理化性质较大影响化合物的血脑屏障通透能力。使用人工智能算法预测血脑屏障通透性，当预测值大于0.75时，意味着该化合物具备良好的透过血脑屏障的潜力，为中枢神经系统药物发现提供了良好的起点。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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  • 生物活性
  • 产品详情
  • 化合物库组成

活性描述 & 特点

Biological Activity

•    A unique collection of 28K BBB-permeable compounds can be used for high throughput screening (HTS) and high content screening (HCS).

•    A useful tool to conduct CNS drug discovery, such as brain tumors, mental disorders, and neurodegenerative diseases.

•    All compounds are screened by AI algorithm, the predicted value is greater than 0.75.

•    All compounds are available off the shelf.

•    LCMS or NMR validation ensures high purity and quality.

产品详情

Product Details

Formulation:

28000 compounds obtained through artificial intelligence (AI) algorithms to predict BBB permeability, providing a promising starting point for CNS drug discovery.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.

Storage:

-80°C

Shipping:

Blue ice or dry ice

化合物库组成

Composition

EGFR (1)

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  •  浓度
  •  形式（固体或溶液）
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联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称：
    MCE CNS BBB Lead-like Library
    目录号：
    HY-L919
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