2. Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease
  3. iGluR Lipoxygenase
  4. Osavampator

Osavampator  (Synonyms: TAK-653)

目录号: HY-115864 纯度: 99.89%
COA 产品使用指南

摩尔计算器

Osavampator (TAK-653) 是一种新型的 AMPA 受体阳性变构调节剂。Osavampator 以谷氨酸依赖方式选择性结合 AMPA-R，诱导 hGluA1i CHO 细胞 Ca2+ 内流 (EC50 = 3.3 μM)。Osavampator 在许多模型里增强学习和记忆能力。Osavampator 目前正在开发用于治疗抑郁症。

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Osavampator Chemical Structure

Osavampator Chemical Structure

CAS No. : 1358751-06-0

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规格 价格 是否有货 数量
5 mg ￥1200
In-stock
10 mg ￥1900
In-stock
25 mg ￥3800
In-stock
50 mg ￥6000
In-stock
100 mg ￥9000
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Osavampator 相关抗体

Top Publications Citing Use of Products

查看 Lipoxygenase 亚型特异性产品:

查看所有亚型
5-LOX 12-LOX 15-LOX

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Osavampator (TAK-653) is a AMPA receptor positive allosteric modulator. Osavampator selectively binds to AMPA-R in a glutamate-dependent manner and induces Ca2+ influx in hGluA1i CHO cells (EC50 = 3.3 μM). Osavampator improves learning and memory in many models. Osavampator is can be used for the research of depressive disorders[1][2].

IC50 & Target

5-LO

 

体内研究
(In Vivo)

Osavampator (0.03-0.3 mg/kg, p.o., single dose) 增强正常大鼠的视觉学习记忆能力[2]。
Osavampator (0.3 mg/kg, p.o., single dose) 增强表现差的大鼠的持续注意力[2]。
Osavampator (0.06 mg/kg, p.o., single dose) 可改善猴的工作记忆[2]。
Osavampator (1 mg/kg, p.o., single dose) 对 RSBM (降低顺从行为模型) 大鼠产生抗抑郁样作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Normal rats[2]
Dosage: 0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg
Administration: Oral gavage (p.o.)
Result: Improved the novelty discrimination index (NDI).
Animal Model: Poor performing rats[2]
Dosage: 0.3 mg/kg
Administration: Oral gavage (p.o.)
Result: Increased correct responses and decreased omissions in the poor performing rats.
Animal Model: Fasted monkey[2]
Dosage: 0.06 mg/kg
Administration: Oral gavage (p.o.)
Result: Significantly increased delayed match-to-sample (DMTS) accuracy at a 16-s delay interval.
Maintained the beneficial effect 24 h after administration.
Animal Model: submissive behavior model [1]
Dosage: 0.1 mg/kg, 1 mg/kg
Administration: Oral gavage (p.o.)
Result: Led to a significant reduction in dominance levels compared with vehicle treatment starting from the seventh day of treatment and maintained throughout the study period.
Had a significant effect in reducing dominance levels at 0.1 and 1 mg/kg.
分子量

373.47

Formula

C19H23N3O3S
CAS 号
性状

固体

颜色

White to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 12.5 mg/mL (33.47 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6776 mL 13.3880 mL 26.7759 mL
5 mM 0.5355 mL 2.6776 mL 5.3552 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.89%

COA (197 KB) HNMR (103 KB) LCMS (267 KB)

产品使用指南 (1538 KB)
参考文献

Osavampator 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6776 mL 13.3880 mL 26.7759 mL 66.9398 mL
5 mM 0.5355 mL 2.6776 mL 5.3552 mL 13.3880 mL
10 mM 0.2678 mL 1.3388 mL 2.6776 mL 6.6940 mL
15 mM 0.1785 mL 0.8925 mL 1.7851 mL 4.4627 mL
20 mM 0.1339 mL 0.6694 mL 1.3388 mL 3.3470 mL
25 mM 0.1071 mL 0.5355 mL 1.0710 mL 2.6776 mL
30 mM 0.0893 mL 0.4463 mL 0.8925 mL 2.2313 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Osavampator1358751-06-0TAK-653TAK653TAK 653iGluRLipoxygenaseIonotropic glutamate receptorsLOXDepressionPoor performing ratsMonkeySubmissive behaviorInhibitorinhibitorinhibit

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