1. Signaling Pathways
  2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker

ADC Linker (ADC连接子)

Antibody-drug conjugates linker

Antibody-drug conjugates (ADCs) consist of a desirable monoclonal antibody, an active cytotoxic drug and an appropriate linker. An appropriate linker between the antibody and the cytotoxic drug provides a specific bridge, and thus helps the antibody to selectively deliver the cytotoxic drug to tumor cells and accurately releases the cytotoxic drug at tumor sites. In addition to conjugation, the linkers maintain ADCs’ stability during the preparation and storage stages of the ADCs and during the systemic circulation period.

The ADCs currently undergoing clinical evaluation contain linkers are mostly classified into two categories: cleavable and noncleavable. Cleavable linkers rely on processes inside the cell to liberate the toxin, such as reduction in the cytoplasm, exposure to acidic conditions in the lysosome, or cleavage by specific proteases within the cell. Noncleavable linkers require proteolytic degradation of the antibody portion of the ADC for release of the cytotoxic molecule, which will retain the linker and the amino acid by which it was attached to the antibody.

The selection of linker is target dependent, based on the knowledge of the internalization and degradation of the antibody-target antigen complex, and a preclinical in vitro and in vivo activity comparison of conjugates. Moreover, the choice of a linker is also influenced by which cytotoxin is used, as each molecule has different chemical constraints, and frequently the drug structure lends itself to a specific linker.

目录号 产品名 作用方式 纯度
  • HY-20336
    Mc-Val-Cit-PABC-PNP 98.80%
    Mc-Val-Cit-PABC-PNP 是一种可降解的 ADC linker,可用于合成抗体偶联药物 (ADC)。
  • HY-W019543
    DSS Crosslinker 99.73%
    DSS Crosslinker 是一种不可降解 (non-cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
  • HY-D0975
    Sulfo-SMCC sodium
    Sulfo-SMCC sodium 是一种常用的异双官能交联剂,是不可降解的 ADC linker,其带有N-羟基琥珀酰亚胺 (NHS) 酯和马来酰亚胺基团,分别与伯胺和巯基反应。
  • HY-78738
    MC-Val-Cit-PAB 99.33%
    MC-Val-Cit-PAB 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
  • HY-42973
    DBCO-NHS ester 99.53%
    DBCO-NHS ester 是一种可降解 (cleavable) 的 ADC linker,用于抗体偶联药物 (ADCs) 的合成。
  • HY-148067
    XMT-1519 conjugate-1
    ΧΜΤ-1519 conjugate-1 (compound 31) 是 HER-2 单克隆抗体 XMT-1519 的连接体,可以用于合成 ADC,增加抗肿瘤活性。
  • HY-150043A
    MDTF
    MDTF 是不可降解 (non-cleavable) 的 ADC linker,用于合成抗体偶联药物 (ADCs)。
  • HY-148245
    OH-Glu-Val-Cit-PAB-MMAE
    OH-Glu-Val-Cit-PAB-MMAE 由可切割的 ADC 连接子 (OH -Glu-Val-Cit-PAB) 和有效的微管蛋白抑制剂 (MMAE) 组成。OH-Glu-Val-Cit-PAB-MMAE 可用于抗体-药物偶联物 (ADC) 的合成。
  • HY-118759
    DSP Crosslinker 98.73%
    DSP Crosslinker 是一种可降解 (cleavable) 的 ADC linker,用于合成可用于合成抗体偶联药物 (ADC)。
  • HY-78921
    Fmoc-3VVD-OH 99.85%
    Fmoc-3VVD-OH 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。
  • HY-12362
    Val-cit-PAB-OH 99.62%
    Val-cit-PAB-OH 是一种可降解的 ADC linker。
  • HY-41189
    Fmoc-Val-Cit-PAB-PNP ≥98.0%
    Fmoc-Val-Cit-PAB-PNP 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。 Fmoc-Val-Cit-PAB-PNP 的血浆稳定性优于不可降解连接剂。
  • HY-42360
    SMCC 99.25%
    SMCC 是一种蛋白质交联剂。SMCC 接合抗原耦合脾脏细胞来诱导抗原特异性免疫反应。
  • HY-78931
    Boc-Dap-NE 98.42%
    Boc-Dap-NE 是一种二肽,用作一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
  • HY-100216
    SPDP ≥98.0%
    SPDP (SPDP Crosslinker) 是一种短链交联剂,可通过 NHS-酯和吡啶基二硫醇反应性基团与半胱氨酸巯基形成可降解 (cleavable) 的 (可还原的) 二硫键,实现胺与巯基的结合。SPDP (SPDP Crosslinker) 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
  • HY-W008005
    Amino-PEG4-alcohol 99.73%
    Amino-PEG4-alcohol 是一种基于 PEG 的 PROTAC linker,可以用于合成 PROTAC。Amino-PEG4-alcohol 也是一个不可降解 (non-cleavable) 的 ADC linker,用于抗体偶联药物 (ADC) 的合成。
  • HY-133540
    Maleimide-DOTA ≥98.0%
    Maleimide-DOTA 是一种不可降解的 ADC linker,用于抗体药物偶联物 (ADC) 合成。
  • HY-78961
    6-Maleimidohexanoic acid N-hydroxysuccinimide ester

    6-(马来酰亚胺基) 己酸琥珀酰亚胺酯

    99.62%
    6-Maleimidohexanoic acid N-hydroxysuccinimide ester (EMCS) 是一种异双官能团交联剂。EMCS 是一种制备半抗原结合物和酶免疫偶联物的独特而有用的试剂。
  • HY-43869
    Vipivotide tetraxetan Ligand-Linker Conjugate 99.95%
    Vipivotide tetraxetan Ligand-Linker Conjugate (PSMA-617 Ligand-Linker Conjugate) 是由一个 Linker 和 Glutamate-urea-Lysine组成,可用于合成 Vipivotide tetraxetan (PSMA-617)。 Glutamate-urea-Lysine 可以与前列腺特异性膜抗原 (PSMA) 选择性结合。
  • HY-42972
    DBCO-acid 99.63%
    DBCO-acid 是一种可降解 (cleavable) ADC linker,可用于合成 ADC linker DBCO-NHS ester (HY-115524 和 HY-115545),及偶联物 DBCO-PEG-MMAE (HY-111012 和 HY-126690)。

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