1. Signaling Pathways
  2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker

ADC Linker (ADC连接子)

Antibody-drug conjugates (ADCs) consist of a desirable monoclonal antibody, an active cytotoxic drug and an appropriate linker. An appropriate linker between the antibody and the cytotoxic drug provides a specific bridge, and thus helps the antibody to selectively deliver the cytotoxic drug to tumor cells and accurately releases the cytotoxic drug at tumor sites. In addition to conjugation, the linkers maintain ADCs’ stability during the preparation and storage stages of the ADCs and during the systemic circulation period.

The ADCs currently undergoing clinical evaluation contain linkers are mostly classified into two categories: cleavable and noncleavable. Cleavable linkers rely on processes inside the cell to liberate the toxin, such as reduction in the cytoplasm, exposure to acidic conditions in the lysosome, or cleavage by specific proteases within the cell. Noncleavable linkers require proteolytic degradation of the antibody portion of the ADC for release of the cytotoxic molecule, which will retain the linker and the amino acid by which it was attached to the antibody.

The selection of linker is target dependent, based on the knowledge of the internalization and degradation of the antibody-target antigen complex, and a preclinical in vitro and in vivo activity comparison of conjugates. Moreover, the choice of a linker is also influenced by which cytotoxin is used, as each molecule has different chemical constraints, and frequently the drug structure lends itself to a specific linker.

ADC Linker 亚型特异性产品:

  • Cleavable

  • Non-cleavable

ADC Linker 相关产品 (641):

目录号 产品名 作用方式 纯度
  • HY-D0975
    Sulfo-SMCC sodium
    Sulfo-SMCC sodium 是一种常用的异双官能交联剂,是不可降解的 ADC linker,其带有N-羟基琥珀酰亚胺 (NHS) 酯和马来酰亚胺基团,分别与伯胺和巯基反应。
  • HY-78738
    MC-Val-Cit-PAB ≥99.0%
    MC-Val-Cit-PAB 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
  • HY-42973
    DBCO-NHS ester 99.53%
    DBCO-NHS ester 是一种可降解 (cleavable) 的 ADC linker,用于抗体偶联药物 (ADCs) 的合成。
  • HY-20336
    Mc-Val-Cit-PABC-PNP 98.80%
    Mc-Val-Cit-PABC-PNP 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
  • HY-78921
    Fmoc-3VVD-OH
    Fmoc-3VVD-OH 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。
  • HY-139441
    DM21
    DM21 是一种可裂解的 ADC 连接子 (ADC linker),可用于抗体偶联药物 (ADCs) 的合成。
  • HY-139107
    Biotin-PEG4-SS-azide
    Biotin-PEG4-SS-azide 是可降解的、生物素标记的 ADC linker,用于合成 ADCs。
  • HY-138745
    Bis-sulfone-PEG3-Azide
    Bis-sulfone-PEG3-Azide 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
  • HY-78931
    Boc-Dap-NE
    Boc-Dap-NE 是一种二肽,用作一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
  • HY-W008005
    Amino-PEG4-alcohol
    Amino-PEG4-alcohol 是一种基于 PEG 的 PROTAC linker,可以用于合成 PROTAC。Amino-PEG4-alcohol 也是一个不可降解 (non-cleavable) 的 ADC linker,用于抗体偶联药物 (ADC) 的合成。
  • HY-100216
    SPDP 98.45%
    SPDP (SPDP Crosslinker) 是一种短链交联剂,可通过 NHS-酯和吡啶基二硫醇反应性基团与半胱氨酸巯基形成可降解 (cleavable) 的 (可还原的) 二硫键,实现胺与巯基的结合。SPDP (SPDP Crosslinker) 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
  • HY-W019543
    DSS Crosslinker ≥98.0%
    DSS Crosslinker 是一种不可降解 (non-cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
  • HY-118759
    DSP Crosslinker
    DSP Crosslinker 是一种可降解 (cleavable) 的 ADC linker,用于合成可用于合成抗体偶联药物 (ADC)。
  • HY-41189
    Fmoc-Val-Cit-PAB-PNP 98.75%
    Fmoc-Val-Cit-PAB-PNP 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
  • HY-12362
    Val-cit-PAB-OH 99.35%
    Val-cit-PAB-OH 是一种可降解的 ADC linker。
  • HY-42360
    SMCC
    SMCC 是一种蛋白质交联剂。SMCC 接合抗原耦合脾脏细胞来诱导抗原特异性免疫反应。
  • HY-130324
    Azido-PEG7-amine
    Azido-PEG7-amine 是一种不可降解 (non-cleavable) 的 7 单元 PEG-ADC 连接物,用于抗体偶联药物 (ADC) 的合成。Azido-PEG7-amine 也是一种基于 PEG 的 PROTAC linker,可用于 PROTAC 的合成。
  • HY-42972
    DBCO-acid 99.63%
    DBCO-acid 是一种可降解 (cleavable) ADC linker,可用于合成 ADC linker DBCO-NHS ester (HY-115524 和 HY-115545),及偶联物 DBCO-PEG-MMAE (HY-111012 和 HY-126690)。
  • HY-44222
    MAC glucuronide linker-2 99.38%
    MAC glucuronide linker-2 是一种可降解 (cleavable) 的 ADC linker,用于抗体偶联药物 (ADCs) 的合成。
  • HY-78961
    6-Maleimidohexanoic acid N-hydroxysuccinimide ester 98.05%
    6-Maleimidohexanoic acid N-hydroxysuccinimide ester (EMCS) 是一种异双官能团交联剂。EMCS 是一种制备半抗原结合物和酶免疫偶联物的独特而有用的试剂。
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