1. Signaling Pathways
  2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker

ADC Linker

Antibody-drug conjugates (ADCs) consist of a desirable monoclonal antibody, an active cytotoxic drug and an appropriate linker. An appropriate linker between the antibody and the cytotoxic drug provides a specific bridge, and thus helps the antibody to selectively deliver the cytotoxic drug to tumor cells and accurately releases the cytotoxic drug at tumor sites. In addition to conjugation, the linkers maintain ADCs’ stability during the preparation and storage stages of the ADCs and during the systemic circulation period.

The ADCs currently undergoing clinical evaluation contain linkers are mostly classified into two categories: cleavable and noncleavable. Cleavable linkers rely on processes inside the cell to liberate the toxin, such as reduction in the cytoplasm, exposure to acidic conditions in the lysosome, or cleavage by specific proteases within the cell. Noncleavable linkers require proteolytic degradation of the antibody portion of the ADC for release of the cytotoxic molecule, which will retain the linker and the amino acid by which it was attached to the antibody.

The selection of linker is target dependent, based on the knowledge of the internalization and degradation of the antibody-target antigen complex, and a preclinical in vitro and in vivo activity comparison of conjugates. Moreover, the choice of a linker is also influenced by which cytotoxin is used, as each molecule has different chemical constraints, and frequently the drug structure lends itself to a specific linker.

ADC Linker Isoform Specific Products:

  • Cleavable

  • Non-cleavable

ADC Linker 相关产品 (607):

Cat. No. Product Name Effect Purity
  • HY-42973
    DBCO-NHS ester 99.00%
    DBCO-NHS ester 是一种可降解 (cleavable) 的 ADC linker,用于抗体偶联药物 (ADCs) 的合成。
  • HY-100216
    SPDP 98.45%
    SPDP (SPDP Crosslinker) 是一种短链交联剂,可通过 NHS-酯和吡啶基二硫醇反应性基团与半胱氨酸巯基形成可降解 (cleavable) 的 (可还原的) 二硫键,实现胺与巯基的结合。SPDP (SPDP Crosslinker) 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
  • HY-78738
    MC-Val-Cit-PAB 99.33%
    MC-Val-Cit-PAB 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
  • HY-78931
    Boc-Dap-NE
    Boc-Dap-NE 是一种二肽,用作一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
  • HY-D0975
    Sulfo-SMCC sodium
    Sulfo-SMCC sodium 是一种常用的异双官能交联剂,是不可降解的 ADC linker,其带有N-羟基琥珀酰亚胺 (NHS) 酯和马来酰亚胺基团,分别与伯胺和巯基反应。
  • HY-W002213
    N-Hydroxysulfosuccinimide sodium >98.0%
    N-Hydroxysulfosuccinimide (sodium) 是一种不可降解 (non-cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
  • HY-W019543
    DSS Crosslinker >98.0%
    DSS Crosslinker 是一种不可降解 (non-cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
  • HY-41189
    Fmoc-Val-Cit-PAB-PNP
    Fmoc-Val-Cit-PAB-PNP 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
  • HY-W008005
    Amino-PEG4-alcohol
    Amino-PEG4-alcohol 是一种基于 PEG 的 PROTAC linker,可以用于合成 PROTAC。Amino-PEG4-alcohol 也是一个不可降解 (non-cleavable) 的 ADC linker,用于抗体偶联药物 (ADC) 的合成。
  • HY-12362
    Val-cit-PAB-OH 99.35%
    Val-cit-PAB-OH 是一种可降解的 ADC linker。
  • HY-42972
    DBCO-acid 98.32%
    DBCO-acid 是一种可降解 (cleavable) ADC linker,可用于合成 ADC linker DBCO-NHS ester (HY-115524 和 HY-115545),及偶联物 DBCO-PEG-MMAE (HY-111012 和 HY-126690)。
  • HY-W007713
    Fmoc-8-amino-3,6-dioxaoctanoic acid 99.45%
    Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) 是一种可降解的 ADC linker,用于抗体药物偶联物 (ADC) 合成。
  • HY-W011561
    Boc-NH-C6-Br
    Boc-NH-C6-Br 是一种可降解 (cleavable) 的 linker,用于抗体偶联药物 (ADC)。
  • HY-20336
    Mc-Val-Cit-PABC-PNP 98.26%
    Mc-Val-Cit-PABC-PNP 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
  • HY-42360
    SMCC >98.0%
    SMCC 是一种蛋白质交联剂。SMCC 接合抗原耦合脾脏细胞来诱导抗原特异性免疫反应。
  • HY-12448
    SPDB 99.30%
    SPDB 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
  • HY-43869
    Vipivotide tetraxetan Linker 99.88%
    Vipivotide tetraxetan Linker (PSMA-617 Linker) 是一种有效的不可降解的肽类 Linker,可用于合成 Vipivotide tetraxetan (PSMA-617)。 Vipivotide tetraxetan (PSMA-617) 是用于合成 177Lu-PSMA-617 的配体,177Lu-PSMA-617 是用于研究前列腺癌的一种放射性分子。
  • HY-44222
    MAC glucuronide linker-2 99.38%
    MAC glucuronide linker-2 是一种可降解 (cleavable) 的 ADC linker,用于抗体偶联药物 (ADCs) 的合成。
  • HY-W000434
    Fmoc-NH-PEG4-CH2CH2COOH
    Fmoc-NH-PEG4-CH2CH2COOH 是一种可降解的 ADC linker,用于抗体药物偶联物 (ADC) 合成。
  • HY-W008352
    Boc-NH-PEG4-CH2CH2NH2
    Boc-NH-PEG4-CH2CH2NH2 是一种可降解 (cleavable) 的 5 单元 PEG 类 ADC linker,用于抗体偶联药物 (ADC) 的合成。
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