1. Signaling Pathways
  2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker

ADC Linker

Antibody-drug conjugates (ADCs) consist of a desirable monoclonal antibody, an active cytotoxic drug and an appropriate linker. An appropriate linker between the antibody and the cytotoxic drug provides a specific bridge, and thus helps the antibody to selectively deliver the cytotoxic drug to tumor cells and accurately releases the cytotoxic drug at tumor sites. In addition to conjugation, the linkers maintain ADCs’ stability during the preparation and storage stages of the ADCs and during the systemic circulation period.

The ADCs currently undergoing clinical evaluation contain linkers are mostly classified into two categories: cleavable and noncleavable. Cleavable linkers rely on processes inside the cell to liberate the toxin, such as reduction in the cytoplasm, exposure to acidic conditions in the lysosome, or cleavage by specific proteases within the cell. Noncleavable linkers require proteolytic degradation of the antibody portion of the ADC for release of the cytotoxic molecule, which will retain the linker and the amino acid by which it was attached to the antibody.

The selection of linker is target dependent, based on the knowledge of the internalization and degradation of the antibody-target antigen complex, and a preclinical in vitro and in vivo activity comparison of conjugates. Moreover, the choice of a linker is also influenced by which cytotoxin is used, as each molecule has different chemical constraints, and frequently the drug structure lends itself to a specific linker.

ADC Linker 相关产品 (12):

Cat. No. Product Name Effect Purity
  • HY-78738
    MC-Val-Cit-PAB 99.66%
    MC-Val-Cit-PAB是可被组织蛋白酶切割的ADC连接桥,用于制备抗体-药物偶联物。 美国FDA批准的药物,如brentuximab vedotin使用了该连接桥。
  • HY-12362
    Val-cit-PAB-OH 99.64%
    Val-cit-PAB-OH是一种多肽前体药物连接子。
  • HY-41189
    Fmoc-Val-Cit-PAB-PNP
    Fmoc-Val-Cit-PAB-PNP是一种多肽前体药物连接子,是抗体偶联药物 (ADC) 的常用连接桥。
  • HY-20336
    Mc-Val-Cit-PABC-PNP 98.68%
    Mc-Val-Cit-PABC-PNP是用于合成抗体-药物偶联物 (ADCs) 的,可切割的组织蛋白酶连接桥 (ADC linker)。
  • HY-78961
    6-Maleimidohexanoic acid N-hydroxysuccinimide ester 99.96%
    6-Maleimidohexanoic acid N-hydroxysuccinimide ester(ECMS)是抗体偶联药物(ADC)中常用保护基团。
  • HY-43869
    Vipivotide tetraxetan Linker
    Vipivotide tetraxetan Linker 是一种有效的肽类接头,可用于合成 Vipivotide tetraxetan (PSMA-617)。 Vipivotide tetraxetan (PSMA-617) 是用于合成 177Lu-PSMA-617 的配体,177Lu-PSMA-617 是用于治疗前列腺癌的一种放射性分子。
  • HY-114430
    Fmoc-Phe-Lys(Boc)-PAB-PNP 98.67%
    Fmoc-Phe-Lys(Boc)-PAB-PNP 是抗体偶联药物 (ADC) 的常用连接桥。
  • HY-111434A
    UAA crosslinker 1 hydrochloride
    UAA crosslinker 1 hydrochloride 是一种用于非标准氨基酸 (ncAAs) 掺入的琥珀色密码子。ncAAs 可利用某些野生型和工程氨基酰-tRNA 合成酶的混杂活性在体内合成蛋白质。
  • HY-19318
    Fmoc-Val-Cit-PAB 98.13%
    Fmoc-Val-Cit-PAB是抗体偶联药物(ADC)的常用连接桥。
  • HY-21210
    6-Quinoxalinecarboxylic acid, 2,3-bis(bromomethyl)-
    6-Quinoxalinecarboxylic acid, 2,3-bis(bromomethyl)- 是抗体偶联药物 (ADC) 的连接桥。
  • HY-20560
    (Ac)Phe-Lys(Alloc)-PABC-PNP
    (Ac)Phe-Lys(Alloc)-PABC-PNP是抗体偶联药物(ADC)的常用连接桥。
  • HY-111434
    UAA crosslinker 1
    UAA crosslinker 1 hydrochloride 是一种用于非标准氨基酸 (ncAAs) 掺入的琥珀色密码子。ncAAs 可利用某些野生型和工程氨基酰-tRNA 合成酶的混杂活性在体内合成蛋白质。
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