1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. Mc-Val-Cit-PABC-PNP

Mc-Val-Cit-PABC-PNP (Synonyms: Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate)

目录号: HY-20336 纯度: 98.76%
产品使用指南

Mc-Val-Cit-PABC-PNP 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

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Mc-Val-Cit-PABC-PNP Chemical Structure

Mc-Val-Cit-PABC-PNP Chemical Structure

CAS No. : 159857-81-5

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Size Price Stock Quantity
Free Sample (0.1-0.5 mg)   Apply now  
10 mg ¥1900 In-stock
50 mg ¥6500 In-stock
100 mg ¥9900 In-stock
200 mg ¥17000 In-stock
500 mg   Get quote  
1 g   Get quote  

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Description

Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

IC50 & Target

Cleavable

 

Molecular Weight

737.76

Formula

C₃₅H₄₃N₇O₁₁

CAS No.

159857-81-5

SMILES

CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1)=O)=O)NC(CCCCCN3C(C=CC3=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 37 mg/mL (50.15 mM)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3555 mL 6.7773 mL 13.5545 mL
5 mM 0.2711 mL 1.3555 mL 2.7109 mL
10 mM 0.1355 mL 0.6777 mL 1.3555 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。 -80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

References

Purity: 98.76%

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Mc-Val-Cit-PABC-PNPMaleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonateADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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产品名称:
Mc-Val-Cit-PABC-PNP
目录号:
HY-20336
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