1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Acetyl-CoA Carboxylase

Acetyl-CoA Carboxylase (乙酰辅酶A羧化酶)

Acetyl-CoA carboxylase catalyzes the ATP-dependent carboxylation of acetyl-CoA, a rate-limiting step in fatty acid biosynthesis. Acetyl-CoA carboxylase has crucial roles in fatty acid metabolism and is an attractive target for drug discovery against diabetes, cancer, and other diseases.

In animals, there are two major isoforms of ACCs, ACC1, and ACC2, which are encoded by different genes and display distinct tissue and cellular distribution. The first committed step of fatty acid synthesis (FASyn) is mediated by ACC, which in mammals is encoded by two related enzymes ACC1 and ACC2, which catalyze the ATP-dependent carboxylation of acetyl-CoA to form malonyl-CoA. ACC1 encodes a cytoplasmic isoform that is thought to be the predominant isoform controlling FASyn, whereas ACC2 is tethered to the mitochondrial outer membrane, where localized malonyl-CoA production blocks carnitine palmitoyltransferase-1 (CPT-1) function to prevent fatty acids from entering the mitochondria to undergo fatty acid oxidation (FAOxn).

Acetyl-CoA Carboxylase 相关产品 (3):

目录号 产品名 作用方式 纯度
  • HY-101068
    TOFA Inhibitor ≥98.0%
    TOFA (RMI14514;MDL14514)是乙酰辅酶A羧化酶-α (ACCA )的变构抑制剂。
  • HY-B2007
    Fluazifop-P-butyl Inhibitor 98.98%
    Fluazifop-P-butyl 是一种来自芳基苯氧基丙酸酯的杀草剂,是一种乙酰辅酶 A 羧化酶 (ACCase) 抑制剂。
  • HY-117262
    Propaquizafop Inhibitor
    Propaquizafop 是抑制苯氧基异丙酸除草剂,也是一种乙酰辅酶 A 羧化酶 (acetyl-coA carboxylase) 抑制剂。
Isoform Specific Products

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