1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Acetyl-CoA Carboxylase

Acetyl-CoA Carboxylase (乙酰辅酶A羧化酶)

Acetyl-CoA carboxylase catalyzes the ATP-dependent carboxylation of acetyl-CoA, a rate-limiting step in fatty acid biosynthesis. Acetyl-CoA carboxylase has crucial roles in fatty acid metabolism and is an attractive target for drug discovery against diabetes, cancer, and other diseases.

In animals, there are two major isoforms of ACCs, ACC1, and ACC2, which are encoded by different genes and display distinct tissue and cellular distribution. The first committed step of fatty acid synthesis (FASyn) is mediated by ACC, which in mammals is encoded by two related enzymes ACC1 and ACC2, which catalyze the ATP-dependent carboxylation of acetyl-CoA to form malonyl-CoA. ACC1 encodes a cytoplasmic isoform that is thought to be the predominant isoform controlling FASyn, whereas ACC2 is tethered to the mitochondrial outer membrane, where localized malonyl-CoA production blocks carnitine palmitoyltransferase-1 (CPT-1) function to prevent fatty acids from entering the mitochondria to undergo fatty acid oxidation (FAOxn).

Acetyl-CoA Carboxylase 相关产品 (13):

目录号 产品名 作用方式 纯度
  • HY-16901
    Firsocostat Inhibitor 99.48%
    Firsocostat (ND-630; GS-0976; NDI-010976) 是乙酰辅酶A羧化酶 (ACC) 抑制剂,抑制人类 ACC1 和 ACC2 的 IC50 值分别为2.1和6.1 nM。
  • HY-101842
    ND-646 Inhibitor 99.53%
    ND-646 是一种有效的乙酰辅酶 A 羧化酶 (ACC) 抑制剂,抑制重组 hACC1 和 hACC2,IC50 分别为 3.5 nM 和 4.1 nM。
  • HY-101068
    TOFA Inhibitor ≥98.0%
    TOFA (RMI14514;MDL14514)是乙酰辅酶A羧化酶-α (ACCA )的变构抑制剂。
  • HY-12942
    PF-05175157 Inhibitor 98.77%
    PF-05175157 是一种广谱乙酰辅酶 A 羧化酶 (ACC) 抑制剂,对 ACC1 (human),ACC2 (human), ACC1 (rat) 和 ACC2 (rat) 的 IC50 值分别为 27.0, 33.0, 23.5 和 50.4 nM。
  • HY-15259A
    CP-640186 hydrochloride Inhibitor 99.81%
    CP-640186 hydrochloride是一种有效且可透过细胞的乙酰辅酶A羧化酶 (ACC)抑制剂,抑制大鼠肝脏ACC1和大鼠骨骼肌ACC2的 IC50为53 nM和61 nM。
  • HY-16946
    CP-610431 Inhibitor
    CP-610431 是一种可逆的、ATP 非竞争性的、同工酶非选择性的乙酰辅酶 A 羧化酶 (ACC) 抑制剂。CP-610431 抑制 ACC1ACC2IC50 约为 50 nM。 CP-610431 可用于代谢综合征的研究。
  • HY-107709
    MK-4074 Inhibitor 99.71%
    MK-4074是乙酰辅酶A羧化酶 (acetyl-CoA carboxylase) 的肝特异性抑制剂,IC50 值约为3nM。
  • HY-17641
    Olumacostat glasaretil Inhibitor ≥98.0%
    Olumacostat glasaretil是乙酰辅酶A羧化酶(ACC)的小分子抑制剂。
  • HY-135981
    CMS-121 Inhibitor ≥99.0%
    CMS-121 是一种喹诺酮衍生物,也是一种口服活性的乙酰辅酶 A 羧化酶 1 (acetyl-CoA carboxylase 1, ACC1) 抑制剂。CMS-121 分别以 EC50 值 为 7 nM 和 200 nM 来保护 HT22 细胞免受缺血和氧化损伤。CMS-121 具有强大的神经保护,抗炎,抗氧化和肾保护作用。
  • HY-B2007
    Fluazifop-P-butyl Inhibitor 98.98%
    Fluazifop-P-butyl 是一种来自芳基苯氧基丙酸酯的杀草剂,是一种乙酰辅酶 A 羧化酶 (ACCase) 抑制剂。
  • HY-15259
    CP-640186 Inhibitor 98.92%
    CP-640186 是一种有效且可透过细胞的 乙酰辅酶A羧化酶 (ACC) 抑制剂,抑制大鼠肝脏 ACC1 和大鼠骨骼肌 ACC2 的 IC50为 53 nM 和 61 nM。
  • HY-117262
    Propaquizafop Inhibitor
    Propaquizafop 是抑制苯氧基异丙酸除草剂,也是一种乙酰辅酶 A 羧化酶 (acetyl-coA carboxylase) 抑制剂。
  • HY-B1856
    Haloxyfop Inhibitor
    Haloxyfop 是一种芳氯氧苯氧丙酸除草剂 (herbicide),广泛应用于阔叶作物的野草。Haloxyfop 对玉米幼苗叶绿体中乙酰辅酶 A 羧化酶 (EC 的抑制作的 IC50 为 0.5 μM,而对豌豆中该酶无影响。
Isoform Specific Products

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