1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Aminoacyl-tRNA Synthetase

Aminoacyl-tRNA Synthetase (氨酰-tRNA合成酶)

Aminoacyl-tRNA synthetases (AARSs) are the enzymes that catalyze the aminoacylation reaction by covalently linking an amino acid to its cognate tRNA in the first step of protein translation. In mammals, AARSs usually exist in free form or in the form of a multi-tRNA synthetase complex (MSC), and the latter consists of eight AARSs and three non-enzymatic AARS-interacting multi-functional proteins (AIMP1/p43, AIMP2/p38, and AIMP3/p18).

AARSs are responsible for the proper pairing of codons on mRNA with amino acids. AARSs are also involved in RNA splicing, transcriptional regulation, translation, and other aspects of cellular homeostasis. Study of these enzymes is of great interest to the researchers due to its pivotal role in the growth and survival of an organism. AARSs are one of the leading targets for developing novel anti-infective agents. Further, unfolding the interesting structural and functional aspects of these enzymes in the last few years has qualified them as a potential drug target against various diseases.

Aminoacyl-tRNA Synthetase 相关产品 (11):

目录号 产品名 作用方式 纯度
  • HY-112862
    Arg-AMS Inhibitor ≥98.0%
    Arg-AMS 是精氨酸 tRNA 合成酶 (arginyl tRNA synthetase) 的有效抑制剂,能够和非核糖体多肽合成酶的 A 结构域紧密结合。
  • HY-112860
    Asp-AMS Inhibitor
    Asp-AMS是天冬氨酸腺苷酸的一个类似物,是 aspartyl-tRNA 合成酶 (aspartyl-tRNA synthetase) 的一个抑制剂,也是线粒体酶 (mitochondrial enzyme) 的强效竞争性抑制剂。
  • HY-108939
    Aminoacyl tRNA synthetase-IN-1 Inhibitor 99.63%
    Aminoacyl tRNA synthetase-IN-1 是细菌中氨酰基 tRNA 合成酶 (aaRS) 的抑制剂。
  • HY-112861A
    Gln-AMS TFA Inhibitor 99.50%
    Gln-AMS (TFA) 是Ia类型的氨酰基-tRNA合成酶 (AARS)抑制剂。 Gln-AMS抑制谷氨酰胺酰-tRNA合成酶Ki 值为1.32 µM。
  • HY-108940
    GlyRS-IN-1 Inhibitor
    GlyRS-IN-1 是一种甘氨酰 tRNA 合酶 (GlyRS) 抑制剂,详细信息可参考专利 WO 2017066459 A1。GlyRS-IN-1 还抑制细菌 (bacteria) 生长。
  • HY-126130
    LysRs-IN-2 Inhibitor 98.69%
    LysRs-IN-2 是一种赖氨酸 tRNA 合成酶 (KRS) 抑制剂,其对恶性疟原虫 KRS (PfKRS) 和小隐孢子虫 KRS (CpKRS) 的 IC50 值分别为 0.015 μM、0.13 μM。
  • HY-108900
    Leu-AMS Inhibitor 99.14%
    Leu-AMS (compound 6),亮氨酸类似物,是一种有效的亮氨酰-tRNA 合成酶 (LRS) 抑制剂,IC50 值为 22.34 nM,Leu-AMS 抑制了LRS 的催化活性,但不影响亮氨酸诱导的 mTORC1 活化。Leu-AMS在癌细胞和正常细胞中显示出细胞毒性,并抑制细菌的生长。
  • HY-136265
    BC-LI-0186 Inhibitor
    BC-LI-0186 是一种有效的选择性亮氨酸 tRNA 合成酶 (Leucyl-tRNA synthetase (LRS)) 与 Ras 相关的 GTP 结合蛋白 D (RagD) 相互作用的抑制剂 (IC50=46.11 nM)。BC-LI-0186 与 LRS 的 RagD 相互作用位点 (Kd=42.1 nM) 竞争,并对 LRS- vps34、LRS- eprs、RagB-RagD 缔合、mTORC1 复合物的形成没有产生影响。BC-LI-0186 能有效抑制肿瘤相关 MTOR 突变体的活性和雷帕霉素耐药癌细胞的生长。BC-LI-0186 可用于肺癌的相关研究。
  • HY-103280
    LysRs-IN-1 Inhibitor
    LysRs-IN-1 是赖氨酸-tRNA 合成酶 (LysRs) 的抑制剂。
  • HY-108900A
    Leu-AMS R enantiomer
    Leu-AMS R enantiomer 是 Leu-AMS 的 R 对映体。 Leu-AMS 是亮氨酰-tRNA 合成酶 (LRS) 的有效抑制剂并抑制细菌的生长。
  • HY-112861
    Gln-AMS Inhibitor
    Gln-AMS 是一种氨基酰基-tRNA 合成酶 (AARS) 抑制剂,与非核糖体多肽合成酶 (NRPS) A 结构域结合。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.