2. Metabolic Enzyme/Protease Anti-infection
  3. Aminoacyl-tRNA Synthetase Fungal
  4. NP-BTA

NP-BTA 是谷氨酰胺酰-tRNA 合成酶 (GlnRS) 的变构抑制剂。NP-BTA 对 Candida albicans 有抗真菌活性，MIC50 为 6.25 μM。

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NP-BTA Chemical Structure

NP-BTA Chemical Structure

CAS No. : 544420-99-7

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NP-BTA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NP-BTA is an allosteric inhibitor for glutaminyl-tRNA synthetase (GlnRS). NP-BTA exhibits antifungal efficacy against Candida albicans, with MIC50 of 6.25 μM[1].

体外研究
(In Vitro)

NP-BTA (300 μM) 通过与 His6-Gln4 结合 (KD 为 180 nM)，抑制 GlnRS，抑制 tRNAGln 的氨酰化，IC50 为 106 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NP-BTA 相关抗体:
体内研究
(In Vivo)

NP-BTA (0.096–0.27 g 2% NP-BTA cream，每天涂抹两次，共 7 天) 可保护免疫抑制的 CD-1 小鼠免受 T. mentagrophytes 分生孢子的感染[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: T. mentagrophytes infected immunosuppressed CD-1 mice[1]
Dosage: 0.096–0.27 g 2% NP-BTA cream
Administration: Topical application, twice daily for 7 days
Result: Reduced fungal burden.
分子量

231.27

Formula

C11H9N3OS
CAS 号
非同位 CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NP-BTA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NP-BTA544420-99-7Aminoacyl-tRNA SynthetaseFungaltRNA Synthetase, aaRSCandida albicansallostericCD-1 miceT. mentagrophytesInhibitorinhibitorinhibit

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