1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. CETP


Cholesteryl ester transfer protein (CETP) is a plasma glycoprotein that promotes reverse cholesterol transport via the exchange of cholesteryl ester (CE) and triglyceride (TG) among lipoproteins. Cholesteryl ester transfer protein (CETP) promotes reverse cholesterol transport via exchange of cholesteryl ester and triglyceride among lipoproteins. CETP has a central role in lipoprotein metabolism.

CETP, a hydrophobic plasma glycoprotein, is a promising target for raising circulating HDL cholesterol (HDL-C) concentrations in humans. CETP is secreted primarily from the liver and plays a critical role in HDL metabolism by facilitating the exchange of cholesteryl esters (CE) from HDL for triglycerides (TG) in apoB-containing lipoproteins, such as LDL and VLDL.

CETP catalyses the exchange of cholesteryl ester and triglyceride between HDL and apoB containing lipoprotein particles. The role of CETP in modulating plasma HDL cholesterol levels in humans is well established and there have been significant efforts to develop CETP inhibitors to increase HDL cholesterol for the treatment of coronary artery disease.

CETP 相关产品 (6):

Cat. No. Product Name Effect Purity
  • HY-12090
    Anacetrapib Inhibitor 98.39%
    Anacetrapib 是一种有效的 CETP 抑制剂,作用于 rhCETP 和 C13S CETP 突变型,IC50 分别为 7.9±2.5 nM 和 11.8±1.9 nM。
  • HY-12089
    Torcetrapib Inhibitor 99.35%
  • HY-13327
    Evacetrapib Inhibitor 99.33%
    Evacetrapib 是一种有效的选择性的 CETP 抑制剂,在人血浆中,抑制人重组 CETP 蛋白 (IC50 为 5.5 nM) 和 CETP 活性,IC50 为 36 nM。
  • HY-14950
    Dalcetrapib Inhibitor 99.46%
    Dalcetrapib (JTT-705; RO-4607381)是rhCETP抑制剂,IC50为0.2 μM,能增加血浆中HDL胆固醇。
  • HY-19614
    BMS-795311 Inhibitor
    BMS-795311 是一种有效的,具有口服活性的胆固醇酯转移蛋白 CETP 抑制剂, IC50 值分别为 4 nM (SPA) 和 0.22 μM (hWPA)。
  • HY-123039
    CP-532623 Inhibitor >99.0%
    CP-532623 是 CETP 抑制剂,可提高高密度脂蛋白胆固醇水平。CP-532623 与 Torcetrapib 的结构相似,并具有高度亲脂性。
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