1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Thrombin

Thrombin

Thrombin is a serine protease that in humans is encoded by the F2 gene. Thrombin is an intriguing coagulation protease demonstrating an array of effects on endothelial cells, vascular smooth muscle cells (VSMC), monocytes, and platelets, all of which are involved in the pathophysiology of atherosclerosis. There is mounting evidence that thrombin acts as a powerful modulator of many processes like regulation of vascular tone, permeability, migration and proliferation of VSMC, recruitment of monocytes into the atherosclerotic lesions, induction of diverse pro-inflammatory markers, and all of these are related to the progression of cardiovascular disease. Recent studies in transgenic mice models indicate that the deletion of the natural thrombin inhibitor heparin cofactor II promotes an accelerated atherogenic state. The combined evidence points to thrombin as a pivotal contributor to vascular pathophysiology. Considering the clinical development of selective anticoagulants including direct thrombin inhibitors.

Thrombin 相关产品 (26):

Cat. No. Product Name Effect Purity
  • HY-12821
    AEBSF hydrochloride Inhibitor 99.76%
    AEBSF hydrochloride 是丝氨酸蛋白酶 的不可逆抑制剂,可抑制例如胰凝乳蛋白酶,激肽释放酶,纤溶酶,凝血酶和胰蛋白酶。
  • HY-114164
    Thrombin
    Thrombin 是一种胰蛋白酶样别构丝氨酸蛋白酶。Thrombin 能够利用凝血酶识别序列对融合蛋白进行位点特异性切割,并可用于消化 GST 标记的蛋白。
  • HY-10163
    Dabigatran Inhibitor >98.0%
    Dabigatran (BIBR 953),口服抗凝剂,是可逆的,竞争性的直接凝血酶 (thrombin) 抑制剂,Ki 为 4.5 nM。Dabigatran (BIBR 953) 也抑制凝血酶诱导的血小板聚集 (IC50=10 nM)。
  • HY-10274
    Dabigatran etexilate Inhibitor 99.79%
    Dabigatran etexilate(BIBR-1048)是口服活性的dabigatran原药,是可逆的直接凝血酶抑制剂(DTI),Ki为4.5 nM。
  • HY-15664
    Bivalirudin TFA Inhibitor 99.76%
    Bivalirudin TFA 是20个氨基多肽,可逆地抑制凝血酶。
  • HY-17567C
    Heparin sodium salt (MW 15kDa) Inhibitor
    Heparin sodium salt (MW 15kDa) (Sodium heparin (MW 15kDa)) 是一种肝素的聚合物,分子量为 15kDa。Heparin sodium salt 是一种抗凝剂,可与 抗凝血酶 III (ATIII) 可逆地结合,大大加快了 ATIII 使 thrombin factor IIafactor Xa 失活的速度。
  • HY-10787
    Ximelagatran Inhibitor >98.0%
    Ximelagatran (H 376/95) 是一种口服活性凝血酶抑制剂,可选择性和竞争性地抑制游离和凝块结合的凝血酶。Ximelagatran 还是一种抗凝药物,具有快速起效的抗凝作用,可预测的,剂量依赖性的药代动力学和药效学。
  • HY-P1929
    Bivalirudin Inhibitor
    Bivalirudin,一种肽类抗凝剂,是直接凝血酶 (thrombin) 抑制剂,可在侵入性心脏病,特别是经皮冠状动脉介入治疗中用于抗凝。
  • HY-10274A
    Dabigatran etexilate mesylate Inhibitor 99.60%
    Dabigatran etexilate mesylate (BIBR 1048MS)是口服活性的dabigatran前药。Dabigatran是可逆的直接凝血酶抑制剂(DTI),Ki为4.5 nM。
  • HY-B0375A
    Argatroban monohydrate Inhibitor 99.95%
    Argatroban (monohydrate) (MD-805 (monohydrate)) 是 thrombin 选择性抑制剂。
  • HY-17378
    Dabigatran ethyl ester Inhibitor 99.26%
    Dabigatran ethyl ester 是新型的口服抗凝化合物和凝血酶抑制剂。
  • HY-77521
    Dabigatran ethyl ester hydrochloride Inhibitor 99.88%
    Dabigatran ethyl ester hydrochloride是有效地核糖基二氢烟酰胺脱氢酶(NQO2)抑制剂,IC50值为0.8 μM;也是凝血酶的抑制剂。
  • HY-B0209
    Metolazone Inhibitor 99.32%
    Metolazone(Zaroxolyn)可抗心力衰竭和高血压。
  • HY-10277
    Odiparcil Inhibitor >99.0%
    Odiparcil (SB-424323) 是一种具有口服活性 beta-d-thioxyloside 类似物,具有抗血栓形成活性,可降低不良出血事件的风险,Odiparcil (SB-424323) 是一种间接凝血酶抑制剂,通过激活抗凝血酶 II (肝素辅助因子 II) 发挥其抗凝血作用。
  • HY-P1000
    Sfllrnpndkyepf Agonist 98.22%
    Sfllrnpndkyepf 是人工合成的 thrombin 受体激动剂肽段。
  • HY-10217
    Thrombin Inhibitor 2 Inhibitor
    Thrombin Inhibitor 2 是小分子 thrombin 抑制剂,源于专利 US8541580B2,化合物 1。 Thrombin Inhibitor 2 具有抗血栓形成的活性。
  • HY-101054
    NQ301 98.89%
    NQ301是一种抗血栓剂; 可抑制胶原蛋白激发的兔血小板聚集,IC50值为10 mg/mL。
  • HY-129056
    Melagatran Inhibitor
    Melagatran 是具有口服活性的 thrombin 直接抑制剂,除凝血酶外,它与凝血级联反应中的任何其他酶或纤溶酶没有相互作用。Melagatran 的抗凝血酶作用不需要内源性辅因子,可能有助于减轻内毒素血症的某些破坏作用。 Melagatran 具有预防动脉阻塞的潜能。
  • HY-B0375
    Argatroban Inhibitor
    Argatroban (MD-805) 是凝血酶选择性抑制剂。
  • HY-10163AS
    Dabigatran D4 hydrochloride Inhibitor
    Dabigatran D4盐酸盐是Dabigatran氘代化合物标准品。
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