1. Metabolic Enzyme/Protease
    Neuronal Signaling
  2. COMT
  3. Nebicapone

Nebicapone (Synonyms: BIA 3-202)

目录号: HY-106405
产品使用指南

Nebicapone (BIA 3-202) 是一种可逆的儿茶酚-O-甲基转移酶 (COMT) 抑制剂,主要通过葡萄糖醛酸化代谢。Nebicapone 主要是外周作用的抑制剂,通过抑制 COMT 降低 L-DOPA 向 3-O-甲基-DOPA 的生物转化,Nebicapone 具有治疗帕金森病的潜力。

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Nebicapone Chemical Structure

Nebicapone Chemical Structure

CAS No. : 274925-86-9

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Description

Nebicapone (BIA 3-202), a reversible catechol-O-methyltransferase (COMT) inhibitor, is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to 3-O-methyl-DOPA by inhibition of COMT, and it is potential for the treatment of Parkinson's disease.[1].

Molecular Weight

273.24

Formula

C₁₄H₁₁NO₅

CAS No.

274925-86-9

SMILES

O=C(C1=CC([N+]([O-])=O)=C(O)C(O)=C1)CC2=CC=CC=C2

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Nebicapone
目录号:
HY-106405
需求量:

Nebicapone

Cat. No.: HY-106405