1. Signaling Pathways
  2. Protein Tyrosine Kinase/RTK
  3. Ephrin Receptor

Ephrin Receptor (Ephrin受体)

Ephrin receptors (Ephs) are a group of receptors that are activated in response to binding ephrin. Ephs form the largest known subfamily of receptor tyrosine kinases (RTKs). Both Ephs and their corresponding ephrin ligands are membrane-bound proteins that require direct cell-cell interactions for Eph receptor activation. Eph/ephrin signaling has been implicated in the regulation of a host of processes critical to embryonic development including axon guidance, formation of tissue boundaries, cell migration, and segmentation. Additionally, Eph/epherin signaling has recently been identified to play a critical role in the maintenance of several processes during adulthood including long-term potentiation, angiogenesis, and stem cell differentiation and cancer. The ability of Ephs and ephrins to mediate a variety of cell-cell interactions places the Eph/ephrin system in an ideal position to regulate a variety of different biological processes during embryonic development.

Ephrin Receptor 相关产品 (4):

Cat. No. Product Name Effect Purity
  • HY-13258A
    NVP-BHG712 Inhibitor 99.93%
    NVP-BHG712 是具有口服活性的EphB4 激酶自身磷酸化 的抑制剂,其对EphA2 和EphB4 的 IC50 值分别为 3.3 nM 和 3 nM。
  • HY-13258
    NVP-BHG712 isomer 99.46%
    NVP-BHG712 isomer,是NVP-BHG712 的位置异构体,与EPHA2和EPHB4显示保守非键结合。
  • HY-P2264
    KYL peptide Inhibitor
    KYL peptide is an EphA4 receptor tyrosine kinase inhibitor (Kd=0.8 μM). KYL peptide inhibits EphA4-EphrinA5 interactions (IC50=6.34 μM). KYL peptide prevents AβO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. KYL peptide also exhibits a long half life in cell culture media (8 and 12 hours in PC3 and C2C12 media respectively).
  • HY-131005
    Ehp inhibitor 2 Inhibitor
    Ehp inhibitor 2 是 Eph 家族酪氨酸激酶抑制剂。
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