1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. GPR55

GPR55

GPR55 (G protein-coupled receptor 55) is a G protein-coupled receptor that in humans is encoded by the GPR55 gene. GPR55, along with GPR119 and GPR18, have been implicated as novel cannabinoid receptors. GPR55 is activated by the plant cannabinoids 9-THC and cannabidiol, and the endocannabinoids anandamide, 2-AG, noladin ether in the low nanomolar range. Recent research suggests that lysophosphatidylinositol and its 2-arachidonoyl derivative may be the endogenous ligands for GPR55, and the receptor appears likely to be a possible target for treatment of inflammation and pain as with the other cannabinoid receptors. The physiological role of GPR55 is unclear. GPR55 has been proposed as a new potential drug target for the treatment of diabetes, Parkinson’s disease, neuropathic pain, and cancer.

GPR55 相关产品 (3):

Cat. No. Product Name Effect Purity
  • HY-10863
    Anandamide Modulator >99.0%
    Anandamide 是一种中枢神经系统的免疫调节剂,不仅通过大麻素受体 (CB1CB2) 且通过其他靶点 (如 GPR18/GPR55) 起作用。
  • HY-16697
    CID 16020046 Antagonist 99.92%
    CID 16020046 是一种有效的,选择性 GPR55 拮抗剂,抑制 GPR55 的组成型活性,IC50 为 0.15 μM。CID 16020046 抑制 GPR55 介导的 Ca2+ 信号传导和 GPR55 介导的 ERK1/2 磷酸化。CID 16020046 降低了内皮细胞的伤口愈合,并参与了血小板功能的调节。
  • HY-116637
    Tetrahydromagnolol Antagonist
    Tetrahydromagnolol (Magnolignan),是 Magnolol 的主要代谢产物,是一种有效的选择性大麻素 CB2 受体激动剂,EC50 为 170 nM,Ki 为 416 nM。Tetrahydromagnolol 对 CB2 受体的选择性比 CB1 受体高 20 倍。Tetrahydromagnolol 也是一种弱的 GPR55 受体拮抗剂。
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