1. GPCR/G Protein
    Neuronal Signaling
  2. Cannabinoid Receptor
    GPR55
  3. Tetrahydromagnolol

Tetrahydromagnolol (Synonyms: Magnolignan)

目录号: HY-116637
产品使用指南

Tetrahydromagnolol (Magnolignan),是 Magnolol 的主要代谢产物,是一种有效的选择性大麻素 CB2 受体激动剂,EC50 为 170 nM,Ki 为 416 nM。Tetrahydromagnolol 对 CB2 受体的选择性比 CB1 受体高 20 倍。Tetrahydromagnolol 也是一种弱的 GPR55 受体拮抗剂。

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Tetrahydromagnolol Chemical Structure

Tetrahydromagnolol Chemical Structure

CAS No. : 20601-85-8

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Description

Tetrahydromagnolol (Magnolignan), a main metabolite of Magnolol, is a potent and selective cannabinoid CB2 receptor agonist with an EC50 of 170 nM and a Ki of 416 nM. Tetrahydromagnolol possesses 20-fold more selective for CB2 receptor than CB1 receptor. Tetrahydromagnolol is also a weak GPR55 receptor antagonist[1].

IC50 & Target[1]

CB2

170 nM (EC50)

CB2

416 nM (Ki)

CB1

9010 nM (EC50)

CB1

2260 nM (Ki)

GPR55 receptor

 

Molecular Weight

270.37

Formula

C₁₈H₂₂O₂

CAS No.

20601-85-8

中文名称

四氢厚朴酚

SMILES

OC1=CC=C(CCC)C=C1C2=CC(CCC)=CC=C2O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

TetrahydromagnololMagnolignanCannabinoid ReceptorGPR55G protein-coupled receptor 55CB2metaboliteMagnololInhibitorinhibitorinhibit

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产品名称:
Tetrahydromagnolol
目录号:
HY-116637
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