1. Signaling Pathways
  2. GPCR/G Protein
  3. GPR84

GPR84

GPR84 is a G protein-coupled receptor for medium-chain fatty acids. GPR84 is a receptor for free fatty acids and can be potently activated by saturated medium-chain free fatty acids (MCFAs) like decanoic acid, undecanoic acid and lauric acid. GPR84, a receptor for medium-length free fatty acids is upregulated on protein level in LPS activated tolerant CD14+ monocytes and THP-1 cells.

GPR84 is activated by MCFAs with the hydroxyl group at the 2- or 3-position more effectively than nonhydroxylated MCFAs. GPR84 is now considered to be a member of FFA-sensing GPCRs. MCFAs with carbon chain lengths of 9–14 activate GPR84, coupling primarily to a pertussis toxin (PTX)-sensitive Gi/o pathway. GPR84 should be a proinflammatory receptor and may be a novel, attractive target for treating chronic low grade inflammation associated-diseases.

GPR84 相关产品 (5):

Cat. No. Product Name Effect Purity
  • HY-100775
    Setogepram sodium salt Antagonist 99.65%
    Setogepram sodium salt (PBI-4050 sodium salt) 是一种具有口服活性的 GPR40 激动剂和 GPR84 拮抗剂或反向激动剂。Setogepram sodium salt 减轻肾,肝和胰腺纤维化。Setogepram sodium salt 具有抗纤维化,抗炎和抗增殖作用。
  • HY-112562
    GPR84 antagonist 8 Antagonist 99.96%
    GPR84 antagonist 8 是一种选择性 GPR84 拮抗剂。
  • HY-12764
    6-OAU Agonist
    6-OAU(GTPL5846; 6-n-octylaminouracil)是GPR84激动剂,在PI assay中EC50值为105nM。
  • HY-135303
    GLPG1205 Antagonist
    GLPG1205 是有效的选择性,具有口服活性的 GPR84 (G 蛋白偶联受体)拮抗剂,表现出良好的 PK/PD 特征。GLPG1205 具有抗炎活性,可以用于治疗肺纤维化。
  • HY-100775A
    Setogepram Antagonist
    Setogepram (PBI-4050) 是一种具有口服活性的 GPR40 激动剂和 GPR84 拮抗剂或反向激动剂。Setogepram (PBI-4050) 减轻肾,肝和胰腺纤维化。Setogepram (PBI-4050) 具有抗纤维化,抗炎和抗增殖作用。
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