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GLI antagonist-1 

目录号: HY-107551
产品使用指南

GLI antagonist-1 是一种有效的 GLI 拮抗剂,IC50 值为 1.1 µM。GLI antagonist-1 显示出抗增殖活性。GLI antagonist-1 降低 GLI1 mRNA 表达。GLI antagonist-1 以剂量依赖性方式抑制集落形成。

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GLI antagonist-1 Chemical Structure

GLI antagonist-1 Chemical Structure

CAS No. : 599150-20-6

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GLI antagonist-1 is a potent GLI antagonist with an IC50 value of 1.1 µM. GLI antagonist-1 shows anti-proliferative activity. GLI antagonist-1 decreases the GLI1 mRNA expression. GLI antagonist-1 inhibits colony formation in a dose-dependent manner[1].

IC50 & Target

IC50: 1.1 µM (GLI)[1]

体外研究
(In Vitro)

GLI antagonist-1 (compound HPI-1) (0-25 µM; 72 h) shows anti-proliferative activity with IC50 values of 29, >25, 20.5 µM for SUM149, MDA-MB-231, SUM159 cells, respectively[1].
GLI antagonist-1 (10 µM; 72 h) decreases the GLI1 mRNA expression in SUM149 cells[1].
GLI antagonist-1 (5, 10, 20 µM) inhibits colony formation in a dose-dependent manner in SUM149 and MDA-MB-231 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: SUM149, MDA-MB-231, SUM159 cells
Concentration: 0-25 µM
Incubation Time: 72 h
Result: Showed anti-proliferative activity with IC50 values of 29, >25, 20.5 µM for SUM149, MDA-MB-231, SUM159 cells, respectively.
分子量

463.52

Formula

C27H29NO6

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
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质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
GLI antagonist-1
目录号:
HY-107551
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