1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. HCN Channel

HCN Channel (HCN通道)

Hyperpolarization activated cyclic nucleotide gated channels

Hyperpolarization- and Cyclic Nucleotide-gated (HCN) channels are a family of six transmembrane domain, single pore-loop, hyperpolarization activated, non-selective cation channels. The HCN family consists of four members (HCN1-4). HCN channels represent the molecular correlates of I(h), a hyperpolarization-activated current best known for its role in controlling heart rate and in the regulation of neuronal resting membrane potential and excitability.

HCN channels are unique among vertebrate voltage-gated ion channels, in that they have a reverse voltage-dependence that leads to activation upon hyperpolarization. HCN channels are encoded by four genes (HCN1-4) and are widely expressed throughout the heart and the central nervous system.

HCN Channel 相关产品 (7):

目录号 产品名 作用方式 纯度
  • HY-101346
    ZD7288 Inhibitor 99.86%
    ZD7288 (ICI D7288) 是一种有选择性的超极化激活的环核苷酸门控 (HCN) 通道阻断剂。
  • HY-B0162A
    Ivabradine hydrochloride

    盐酸伊伐布雷定

    Inhibitor 99.61%
    Ivabradine hydrochloride 是一种有效且具有口服活性的HCN (超极化激活的环核苷酸门控) 通道阻滞剂,可抑制心脏起搏器电流 (If)。Ivabradine hydrochloride 以剂量依赖性降低心率而不改变血压。Ivabradine hydrochloride 具有抗惊厥、抗缺血和抗心绞痛活性。
  • HY-13422
    Zatebradine hydrochloride

    盐酸扎替雷定

    Antagonist 99.30%
    Zatebradine (UL-FS-49 (free base)) 是一种高效的 HCN Channel 抑制剂,其 IC50 值为 1.96 µM。Zatebradine 会阻止通过人类 HCN1HCN2HCN3HCN4 通道的缓慢内向电流,其 IC50 值分别为 1.83 µM,2.21 µM,1.90 µM 和 1.88 µM。
  • HY-13422A
    Zatebradine

    扎替雷定

    Antagonist 99.0%
    Zatebradine (UL-FS-49 (free base); UL-FS-49CL (free base)) 是一种高效的 HCN Channel 抑制剂,其 IC50 值为 1.96 µM。Zatebradine 会阻止通过人类 HCN1HCN2HCN3HCN4 通道的缓慢内向电流,其 IC50 值分别为 1.83 µM,2.21 µM,1.90 µM 和 1.88 µM。 .
  • HY-18940A
    Cilobradine hydrochloride

    西洛雷定盐酸盐

    Inhibitor ≥99.0%
    Cilobradine是一种HCN通道阻断剂。
  • HY-B0162
    Ivabradine

    伊伐布雷定

    Inhibitor
    Ivabradine 是一种有效且具有口服活性的 HCN (超极化激活的环核苷酸门控) 通道阻滞剂,可抑制心脏起搏器电流 (If)。Ivabradine 以剂量依赖性降低心率而不改变血压。Ivabradine 具有抗惊厥、抗缺血和抗心绞痛活性。
  • HY-101346S
    ZD 7288-d3 Inhibitor
    ZD 7288-d3 (ICI D7288-d3) 是 ZD7288 的氘代物。ZD7288 (ICI D7288) 是一种有选择性的超极化激活的环核苷酸门控 (HCN) 通道阻断剂。