1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. HCN Channel

HCN Channel

Hyperpolarization- and Cyclic Nucleotide-gated (HCN) channels are a family of six transmembrane domain, single pore-loop, hyperpolarization activated, non-selective cation channels. The HCN family consists of four members (HCN1-4). HCN channels represent the molecular correlates of I(h), a hyperpolarization-activated current best known for its role in controlling heart rate and in the regulation of neuronal resting membrane potential and excitability.

HCN channels are unique among vertebrate voltage-gated ion channels, in that they have a reverse voltage-dependence that leads to activation upon hyperpolarization. HCN channels are encoded by four genes (HCN1-4) and are widely expressed throughout the heart and the central nervous system.

HCN Channel 相关产品 (4):

Cat. No. Product Name Effect Purity
  • HY-101346
    ZD7288 Inhibitor 99.79%
    ZD7288 是一种有选择性的超极化激活的环核苷酸门控 (HCN) 通道阻断剂。
  • HY-13422A
    Zatebradine Antagonist 98.80%
    Zatebradine (UL-FS-49 free base) 是 HCN 离子通道高效拮抗剂,可逆性降低心率,10 uM 浓度可抑制 hHCN1 达 92%。
  • HY-13422
    Zatebradine hydrochloride Antagonist 99.15%
    Zatebradine hydrochloride (UL-FS-49; UL-FS-49CL) 是HCN离子通道高效拮抗剂,可逆性降低心率,10uM浓度可抑制hHCN1达92%。
  • HY-18940A
    Cilobradine hydrochloride Inhibitor
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