1. Membrane Transporter/Ion Channel
  2. HCN Channel
  3. Ivabradine

Ivabradine  (Synonyms: 伊伐布雷定)

目录号: HY-B0162
产品使用指南

Ivabradine 是一种有效且具有口服活性的 HCN (超极化激活的环核苷酸门控) 通道阻滞剂,可抑制心脏起搏器电流 (If)。Ivabradine 以剂量依赖性降低心率而不改变血压。Ivabradine 具有抗惊厥、抗缺血和抗心绞痛活性。

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Ivabradine Chemical Structure

Ivabradine Chemical Structure

CAS No. : 155974-00-8

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Top Publications Citing Use of Products

    Ivabradine purchased from MCE. Usage Cited in: J Cell Physiol. 2019 Feb;234(2):1925-1936.  [Abstract]

    Protein expression levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 are detected by western blotting.
    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity[1][2][3][4].

    体内研究
    (In Vivo)

    Ivabradine (1, 10, 20 mg/kg; i.p.) shows anticonvulsant and neuroprotective action in mice[3].
    Ivabradine (5, 10, 20 mg/kg;p.o.; daily for 1 weeks) lowers heart rate in mice with enhanced sympathoadrenergic activities[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 25-30 g, 6 weeks male Swiss mice[3]
    Dosage: 1, 10, 20 mg/kg
    Administration: I.p.; for 3 days
    Result: Attenuated PTZ- and PICRO-induced seizures while presented an antioxidant effect in all brain areas studied, and reduced cleaved caspase-3 expression in the CA1 and DG region of PICRO- and PTZ-treated mice, respectively.
    Animal Model: 3-4 months transgenic (TG) mice with cardiac-restricted overexpression of b2AR[4]
    Dosage: 5, 10, 20 mg/kg
    Administration: P.o; daily for 1 weeks
    Result: Reduced the maximal HR increase in response to the b-agonist isoproterenol, without modifying the response of contractile parameters at 10 mg/kg.
    Clinical Trial
    分子量

    468.59

    Formula

    C27H36N2O5

    CAS 号
    中文名称

    伊伐布雷定

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    纯度 & 产品资料
    参考文献
    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    产品名称:
    Ivabradine
    目录号:
    HY-B0162
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