1. Signaling Pathways
  2. Anti-infection
    Metabolic Enzyme/Protease
  3. HCV Protease

HCV Protease

HCV NS3-4A serine protease is a non-covalent heterodimer consisting of a catalytic subunit (the N-terminal one-third of NS3 protein) and an activating cofactor (NS4A protein), and is responsible for cleavage at four sites of the HCV polyprotein. HCV NS3-4A protease is essential for viral replication in cell culture and in chimpanzees, and has been considered as one of the most attractive targets for developing novel anti-HCV therapies. However, discovery of small-molecule, selective inhibitors against HCV NS3-4A protease as oral drug candidates has been hampered by its shallow substrate-binding groove and the lack of robust, reproducible viral replication models in cell culture or in small animals.

HCV Protease 相关产品 (4):

Cat. No. Product Name Effect Purity
  • HY-30234A
    Clemizole hydrochloride Inhibitor 99.99%
    Clemizole hydrochloride 是一种 H1 组胺受体 (H1 histamine receptor) 拮抗剂,抑制 HCV 复制。
  • HY-N7672
    Isoeuphorbetin Inhibitor
    Isoeuphorbetin,一种从 Viola philippica 中分离的二聚香豆素,是一种强效 HCV 蛋白酶 (HCV protease) 抑制剂,IC50 为 3.63 µg/mL。
  • HY-P2502
    Hepatitis Virus C NS3 Protease Inhibitor 2 Inhibitor
    Hepatitis Virus C NS3 Protease Inhibitor 2 是基于产物的丙型肝炎病毒蛋白酶 ( HCV NS3 protease) 肽抑制剂,其 Ki 值为 41 nM。
  • HY-30234
    Clemizole Inhibitor
Isoform Specific Products

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.