1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. HIV Integrase

HIV Integrase

HIV Integrase is an enzyme produced by a HIV that enables its genetic material to be integrated into the DNA of the infected cell. IN is a key component in the retroviral pre-integration complex (PIC). All retroviral integrase proteins contain three canonical domains, connected by flexible linkers: an N-terminal HH-CC zinc-binding domain, a catalytic core domain and a C-terminal DNA-binding domain. Integration occurs following production of the double-stranded viral DNA by the viral RNA/DNA-dependent DNA polymerase reverse transcriptase. The main function of IN is to insert the viral DNA into the host chromosomal DNA, a step that is essential for HIV replication. Integration is a point of no return for the cell, which becomes a permanent carrier of the viral genome (provirus). Integration is in part responsible for the persistence of retroviral infections.

HIV Integrase 相关产品 (13):

Cat. No. Product Name Effect Purity
  • HY-14740
    Elvitegravir Inhibitor 99.92%
    Elvitegravir (GS-9137; JTK-303; D06677) 是一种 HIV integrase 抑制剂,作用于 HIV-1IIIB,HIV-2EHO 和 HIV-2RODIC50 分别为 0.7 nM,2.8 nM 和 1.4 nM。
  • HY-10353
    Raltegravir Inhibitor 98.11%
  • HY-10353A
    Raltegravir potassium salt Inhibitor 99.96%
    Raltegravir potassium salt (MK 0518 potassium salt) 是一种有效的 integrase 抑制剂,用于研究 HIV 感染。
  • HY-18601
    (±)-BI-D Inhibitor
  • HY-B1408
    Salicylanilide Inhibitor 99.90%
    Salicylanilide 表现出广泛的生物学特性,包括通过抑制靶向 HIV-1 整合酶 (HIV-1 integrase) 或逆转录酶来抑制 HIV 病毒 (HIV virus) 的抗病毒效力。
  • HY-N1347
    Robinetin Inhibitor
    Robinetin (3,3',4',5',7-Pentahydroxyflavone) 是一种天然黄酮,具有显着的“两种颜色”固有荧光特性,具有抗真菌、抗病毒、抗菌、抗突变和抗氧化活性。Robinetin 还可以抑制脂质过氧化和蛋白质糖基化。
  • HY-N0457A
    L-Chicoric Acid Inhibitor 99.98%
    L-Chicoric Acid ((-)-Chicoric acid) 是一种二咖啡酰酒石酸,是一种有效的,选择性的和可逆的 HIV-1 整合酶 (HIV-1 integrase) 抑制剂,IC50 约为 100 nM。L-Chicoric Acid 还可抑制组织培养物中的 HIV-1 的复制。
  • HY-13025
    HIV-1 integrase inhibitor Inhibitor 98.64%
    HIV-1 integrase inhibitor 可用于抗HIV。
  • HY-107485
    HIV-1 integrase inhibitor 8 Inhibitor
    HIV-1 integrase inhibitor 8 是 HIV-1 整合酶 (HIV-1 integrase) 抑制剂,化合物 8。
  • HY-N6711
    Equisetin Inhibitor
    Equisetin 是从陆生真菌 Fusarium equiseti NRRL 5537 中分离出的 N-甲基丝氨酸衍生的酰基特拉姆酸,它作为一种含有四联体的天然产物,具有抗生素和细胞毒活性,可以抑制革兰氏阳性菌的生长和 HIV-1 整合酶活性,但对革兰氏阴性菌没有活性。Equisetin 是一种群体感应抑制剂 (QSI),可减弱铜绿假单胞菌中 QS 调节的毒性表型而不影响细菌的生长,是研究铜绿假单胞菌感染的主要化合物。
  • HY-130760
    HIV-1 integrase inhibitor 7 Inhibitor
    HIV-1 integrase inhibitor 7 是有效的 HIV-1 整合酶抑制剂,IC50 值为 33.3 nM。
  • HY-108820
    HIV-1 integrase inhibitor 4 Inhibitor
    HIV-1 integrase inhibitor 4 是一种 HIV-1 整合酶链转移 (INST) 抑制剂,其 IC50 值为 3.7 nM。
  • HY-108817
    HIV-1 integrase inhibitor 3 Inhibitor
    HIV-1 integrase inhibitor 3 是一种 HIV-1 整合酶链转移 (INST) 抑制剂,其 IC50 值为 2.7 nM。
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