1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. Haspin Kinase

Haspin Kinase (Haspin激酶)

Haspin is a protein kinase that regulates chromosome and spindle function during mitosis and meiosis. Haspin expression is detected in fetal liver, skin, kidney, small intestine and in all proliferating cells. Haspin phosphorylates H3 thr3 (H3T3ph) in human cell lines and depletion of Haspin by RNA interference reveals that Haspin is required for H3 thr3 phosphorylation in mitotic cells. Phosphorylation of H3T3ph by Haspin is necessary for chromosomal passenger complex (CPC) accumulation at centromeres. H3T3ph then positions the CPC at centromeres to regulate selected targets of Aurora B during mitosis.

Haspin Kinase 相关产品 (4):

目录号 产品名 作用方式 纯度
  • HY-15217
    CHR-6494 Inhibitor 98.70%
    CHR-6494 是一种有效的 haspin 抑制剂,能够抑制组蛋白 H3T3 的磷酸化,IC50 值为 2 nM。
  • HY-13455A
    LDN-192960 hydrochloride Inhibitor ≥98.0%
    LDN-192960 hydrochloride 是 HaspinDYRK2 的双重抑制剂,IC50 值分别为 10 nM 和 48 nM。
  • HY-110320
    LDN-209929 dihydrochloride Inhibitor ≥98.0%
    LDN-209929 dihydrochloride 是一种有效和选择性的 haspin kinase 抑制剂 (IC50=55 nM),具有 180 倍的选择性,比 DYRK2 (IC50=9.9 μM)。LDN-209929 是 LDN-192960 (HY-13455) 的优化物。
  • HY-13455
    LDN-192960 Inhibitor 99.56%
    LDN-192960 是 HaspinDYRK2 的双重抑制剂,IC50 值分别为 10 nM 和 48 nM。
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