1. Cell Cycle/DNA Damage
    Protein Tyrosine Kinase/RTK
  2. Haspin Kinase
    DYRK
  3. LDN-192960 hydrochloride

LDN-192960 hydrochloride 

目录号: HY-13455A 纯度: >98.0%
产品使用指南

LDN-192960 hydrochloride 是 HaspinDYRK2 的双重抑制剂,IC50 值分别为 10 nM 和 48 nM。

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LDN-192960 hydrochloride Chemical Structure

LDN-192960 hydrochloride Chemical Structure

CAS No. : 2309172-48-1

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10 mg ¥5500 In-stock
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Description

LDN-192960 hydrochloride is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively[1].

IC50 & Target

IC50: 10 nM (Haspin); 48 nM (DYRK2)[1]

In Vitro

LDN-192960 hydrochloride (10 μM) is selective and inhibits ten of the other kinases by ≥90%, with only five being potently inhibited (IC50<1 μM), including CLK1 (IC50=0.21 μM), DYRK1A (IC50= 0.10 μM), DYRK2 (IC50=2 nM), DYRK3 (IC50=19 nM) and PIM1 (IC50=0.72 μM)[1].

Molecular Weight

401.35

Formula

C₁₈H₂₂Cl₂N₂O₂S

CAS No.

2309172-48-1

SMILES

NCCCSC1=C(C=C(OC)C=C2)C2=NC3=CC=C(OC)C=C31.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Keywords:

LDN-192960LDN192960LDN 192960Haspin KinaseDYRKDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseInhibitorinhibitorinhibit

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产品名称:
LDN-192960 hydrochloride
目录号:
HY-13455A
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