1. Stem Cell/Wnt
  2. Hedgehog
  3. Robotnikinin

Robotnikinin 是一个能够结合和抑制 Smo上游 Sonic Hedgehog (Shh) 信号的小分子。

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Robotnikinin Chemical Structure

Robotnikinin Chemical Structure

CAS No. : 1132653-79-2

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo[1][2].

体外研究
(In Vitro)

Robotnikinin demonstrates ShhN-binding capacity at concentrations between 1.56 μM and 25 μM, with a KD of 3.1 μM derived from kinetic data[2].
Robotnikinin (50 µM) prevents the ShhN-induced LC3-II increase[3].
Robotnikinin (5 μM) downregulates classical NF-κB pathway proteins in H929 and U266 cell lines cocultured with HS-5 cells, suggesting a link between Hh signaling and the NF-κB pathway in MM[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[4]

Cell Line: NCI-H929 or U266 cells.
Concentration: 5 μM.
Incubation Time: 48 h.
Result: Downregulated classical NF-κB pathway proteins in H929 and U266 cell lines cocultured with HS-5 cells.
分子量

454.95

Formula

C25H27ClN2O4

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

纯度 & 产品资料
参考文献

Robotnikinin 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Robotnikinin
目录号:
HY-100515
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