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  3. Robotnikinin

Robotnikinin 

目录号: HY-100515
产品使用指南

Robotnikinin 是一个能够结合和抑制 Smo上游 Sonic Hedgehog (Shh) 信号的小分子。

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Robotnikinin Chemical Structure

Robotnikinin Chemical Structure

CAS No. : 1132653-79-2

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo[1][2].

体外研究
(In Vitro)

Robotnikinin demonstrates ShhN-binding capacity at concentrations between 1.56 μM and 25 μM, with a KD of 3.1 μM derived from kinetic data[2].
Robotnikinin (50 µM) prevents the ShhN-induced LC3-II increase[3].
Robotnikinin (5 μM) downregulates classical NF-κB pathway proteins in H929 and U266 cell lines cocultured with HS-5 cells, suggesting a link between Hh signaling and the NF-κB pathway in MM[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[4]

Cell Line: NCI-H929 or U266 cells.
Concentration: 5 μM.
Incubation Time: 48 h.
Result: Downregulated classical NF-κB pathway proteins in H929 and U266 cell lines cocultured with HS-5 cells.
分子量

454.95

Formula

C25H27ClN2O4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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Robotnikinin
目录号:
HY-100515
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