1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Hexokinase

Hexokinase (己糖激酶)

Hexokinases (HK) play a central role in cellular glucose metabolism. Hexokinasescatalyse the first obligatory step of glucose metabolism, the ATP-dependent phosphorylation of glucose (Glc) to yield glucose-6-phosphate (Glc-6-P). In addition to maintaining the downhill concentration gradient that permits facilitated glucose entry into cells, this reaction constitutes the first step of all major pathways of glucose utilization, including glycolysis, the pentose phosphate pathway, (PPP) and glycogenesis. As such hexokinases are uniquely positioned to influence the extent and direction of glucose flux within the cell. The PPP represents the principal cellular source of NADPH and plays important roles in redox homeostasis, anabolism and nucleotide synthesis (Rib-5-P, ribulose 5-phosphate). Similarly, glycolysis and glycogenesis play important roles in energy metabolism and storage, respectively. Other important cellular functions, including hexosamine and nucleotide sugar generation for glycosaminoglycan and glycoprotein biosynthesis, also require Glc-6-P as a precursor (UDP-Glc, uridine diphosphate glucose; UDP-GlcNAc, uridine diphosphate N-acetylglucosamine).

Hexokinase 相关产品 (3):

目录号 产品名 作用方式 纯度
  • HY-13966
    2-Deoxy-D-glucose Inhibitor ≥99.0%
    2-Deoxy-D-glucose 是一种葡萄糖类似物,为葡萄糖代谢抑制剂,通过作用于己糖激酶 (hexokinase) 来抑制糖酵解 (glycolysis)。
  • HY-19992
    3-Bromopyruvic acid Inhibitor ≥98.0%
    3-Bromopyruvic acid 是己糖激酶 II (hexokinase II, HXK II) 抑制剂,是一种有效的针对肝癌细胞的抗肿瘤剂。
  • HY-B0486
    Lonidamine Inhibitor 99.45%
    Lonidamine (AF-1890),一种抗肿瘤药物,是己糖激酶线粒体丙酮酸载体 (分离的大鼠肝线粒体中的 Ki 2.5 μM) 和质膜单羧酸转运蛋白抑制剂,同时也抑制线粒体复合物 II。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.