1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. VDAC

VDAC (电压依赖性阴离子通道)

Voltage-dependent anion channels (VDACs) are a class of porin ion channel located on the outer mitochondrial membrane. This major protein of the outer mitochondrial membrane of eukaryotes forms a voltage-dependent anion-selective channel (VDAC) that behaves as a general diffusion pore for small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane. Additionally, VDAC is an important regulator of Ca2+ transport in and out of the mitochondria.

VDAC 相关产品 (2):

Cat. No. Product Name Effect Purity
  • HY-15763
    Erastin Inhibitor 99.72%
    Erastin 是铁诱导的细胞死亡 (ferroptosis) 诱导剂。Erastin 结合且抑制电压依赖性阴离子通道 (VDAC2/VDAC3)。
  • HY-108937
    NSC 15364 Inhibitor 99.06%
    NSC 15364 是一种 VDAC1 寡聚化和细胞凋亡 (apoptosis) 抑制剂。
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