1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. VDAC

VDAC (电压依赖性阴离子通道)

Voltage-dependent anion channel

VDAC (voltage-dependent anion selective channel) proteins, also known as mitochondrial porins, are the most abundant proteins of the outer mitochondrial membrane (OMM) where they play a vital role in various cellular processes, in the regulation of metabolism, and in survival pathways. They mediate the ions (such as Ca2+) and metabolites (such as succinate or ATP, tRNA or DNA) exchange between mitochondria and the rest of the cell, ensuring good functionality of mitochondrial complexes and energy production.

In higher eukaryotes, there are three VDAC isoforms (VDAC1, VDAC2, VDAC3) encoded by separate genes located on different chromosomes. VDAC has the potential for the research of cancer and Alzheimer's disease.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-15763
    Erastin Inhibitor 99.76%
    Erastin 是一种铁死亡 (ferroptosis) 诱导剂。Erastin 的铁死亡诱导机制与 ROS 和铁依赖性信号传导有关。Erastin 能够抑制电压依赖性阴离子通道 (VDAC2/VDAC3),加速氧化,导致内源活性氧积累。Erastin 还破坏线粒体通透性过渡孔 (mPTP),表现出抗肿瘤活性。
    Erastin
  • HY-D0086
    DIDS sodium salt Inhibitor 99.13%
    DIDS sodium salt (MDL101114ZA) 是 ABCA1VDAC1 的双抑制剂。
    DIDS sodium salt
  • HY-108937
    NSC 15364 Inhibitor 99.75%
    NSC 15364 是一种 VDAC1 寡聚化和细胞凋亡 (apoptosis) 抑制剂。
    NSC 15364
  • HY-128777
    WEHI-9625 Inhibitor 99.46%
    WEHI-9625 是一种首创的,三环砜小分子凋亡抑制剂,EC50 值为 69 nM。WEHI-9625 与 VDAC2 结合可促进其抑制小鼠 BAK 诱导的细胞凋亡的能力,但对人 BAK 和与凋亡效应密切相关的 BAX 因子均完全无效。
    WEHI-9625
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