1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. VDAC

VDAC (电压依赖性阴离子通道)

Voltage-dependent anion channels (VDACs) are a class of porin ion channel located on the outer mitochondrial membrane. This major protein of the outer mitochondrial membrane of eukaryotes forms a voltage-dependent anion-selective channel (VDAC) that behaves as a general diffusion pore for small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane. Additionally, VDAC is an important regulator of Ca2+ transport in and out of the mitochondria.

VDAC 相关产品 (4):

目录号 产品名 作用方式 纯度
  • HY-15763
    Erastin Inhibitor 99.72%
    Erastin 是铁诱导的细胞死亡 (ferroptosis) 诱导剂。Erastin 结合且抑制电压依赖性阴离子通道 (VDAC2/VDAC3)。
  • HY-D0086
    DIDS sodium salt Inhibitor ≥99.0%
    DIDS sodium salt (MDL101114ZA) 是 ABCA1VDAC1 的双抑制剂。
  • HY-108937
    NSC 15364 Inhibitor 99.27%
    NSC 15364 是一种 VDAC1 寡聚化和细胞凋亡 (apoptosis) 抑制剂。
  • HY-128777
    WEHI-9625 Inhibitor 99.05%
    WEHI-9625 是一种首创的,三环砜小分子凋亡抑制剂,EC50 值为 69 nM。WEHI-9625 与 VDAC2 结合可促进其抑制小鼠 BAK 诱导的细胞凋亡的能力,但对人 BAK 和与凋亡效应密切相关的 BAX 因子均完全无效。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.