1. Signaling Pathways
  2. MAPK/ERK Pathway
  3. MAPKAPK2 (MK2)

MAPKAPK2 (MK2) 

MAP kinase-activated protein kinase 2 (MAPKAPK2) is an enzyme that in humans is encoded by the MAPKAPK2 gene. MAPKAP kinase-2 (MK2) is originally identified by its phosphorylation of glycogen synthase at serine-7 and the corresponding serine in a peptide (GS peptide-1) modelled after the N-terminus of glycogen synthase.

MAPKAP kinase-2 is a novel protein kinase activated by mitogen-activated protein kinase. This MAP kinase activated protein kinase, termed MAPKAP kinase-2, is distinguished from S6 kinase-II (MAPKAP kinase-1) by its response to inhibitors, lack of phosphorylation of S6 peptides and amino acid sequence.

MAPKAPK2 (MK2) 相关产品 (8):

目录号 产品名 作用方式 纯度
  • HY-12834A
    MK2-IN-1 hydrochloride Inhibitor 99.19%
    MK2-IN-1 hydrochloride 是MAPKAPK2(MK2)激酶高效选择性抑制剂,IC50值0.11uM。
  • HY-107427
    PF-3644022 Inhibitor ≥99.0%
    PF-3644022 是一种有效的,选择性的,口服活性的,具有 ATP 竞争性的 MAPKAPK2 (MK2) 抑制剂,IC50 为 5.2 nM,Ki 为 3 nM。PF-3644022 还抑制 MK3 和 p38 调节/激活激酶 (PRAK),IC50 分别为 53 nM 和 5.0 nM。PF-3644022 有效抑制 TNFα 的产生并具有抗炎作用。
  • HY-131249
    MK2-IN-3 Inhibitor 98.21%
    MK2-IN-3 是一种有效和选择性的 MAPKAP-K2 (MK-2) 抑制剂,IC50 值为 8.5 nM。MK2-IN-3 对 MK-3,MK-5,ERK2,MNK1,p38a (IC50=0.21, 0.081, 3.44, 5.7, >100 μM) 和 MSK1,MSK2,CDK2,JNK2,IKK2 (IC50>200 μM) 表现出良好的选择性。MK2-IN-3 可以减少 U937 细胞和体内 TNFα 的产生。
  • HY-108643
    CMPD1 Inhibitor ≥99.0%
    CMPD1 是一种选择性且非 ATP 竞争性的 p38 MAPK 介导的 MK2 磷酸化抑制剂,表观 Ki (Kiapp) 值为 330 nM。
  • HY-112457
    MK2-IN-3 hydrate Inhibitor ≥99.0%
    MK2-IN-3 hydrate (compound 16) 是一种具有口服活性的,选择性的,ATP 竞争性的 MAPKAP-K2 (MK-2) 抑制剂,IC50 值为 0.85 nM。MK2-IN-3 hydrate 对 MK-3 (IC50=0.21 μM), MK-5 (IC50=0.081 μM), ERK2 (IC50=3.44 μM), MNK1(IC50=5.7 μM) 以及 CDK2, JNK2, IKK2, MSK1, and MSK2 也具有选择性。
  • HY-139553
    Zunsemetinib Inhibitor
    Zunsemetinib (CDD-450) 是一种具有口服活性的 p38α 丝裂原激活蛋白激酶激活蛋白激酶2 (MK2)通路抑制剂。Zunsemetinib 可用于免疫炎症性疾病的研究。
  • HY-139504
    CC-99677 Inhibitor
    CC-99677 是一种有效的、共价的、不可逆的丝裂原活化蛋白 (MAP) 激酶活化蛋白激酶 -2 (MK2)通路抑制剂,在生化(IC50=156.3 nM) 和细胞基础检测 (EC50=89 nM) 中均有作用。CC-99677 来自专利 WO2020236636,化合物 1。
  • HY-12834
    MK2-IN-1 Inhibitor
    MK2-IN-1是MAPKAPK2(MK2)激酶高效选择性抑制剂,IC50值0.11uM。
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