2. Metabolic Enzyme/Protease MAPK/ERK Pathway GPCR/G Protein Apoptosis
  3. Tyrosinase Ras Raf MAPKAPK2 (MK2) Apoptosis
  4. Norartocarpetin

Norartocarpetin 是一种酪氨酸酶抑制剂。Norartocarpetin 具有较强的酪氨酸酶抑制活性，其抑制活性 IC50 值为 0.47 μM。Norartocarpetin 作为一种抗褐变剂可用于食品体系的研究。Norartocarpetin 对肺癌细胞 (NCI-H460) 也具有显著的抗癌活性，其 IC50 值为 22 μM。Norartocarpetin 的抗增殖作用是通过靶向 Ras/Raf/MAPK 信号通路、线粒体介导的细胞凋亡、S 期细胞周期阻滞和抑制细胞迁移和侵袭实现的。

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Norartocarpetin Chemical Structure

Norartocarpetin Chemical Structure

CAS No. : 520-30-9

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1 mg ￥1400
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5 mg ￥3500
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10 mg ￥5800
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Norartocarpetin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Norartocarpetin is a tyrosinase inhibitor. Norartocarpetin has strong tyrosinase inhibitory activity with an IC50 value of 0.47 μM. Norartocarpetin as an antibrowning agent can be used for the research of food systems. Norartocarpetin also has a significant anticancer activity in lung carcinoma cells (NCI-H460) with an IC50 value of 22 μM. Norartocarpetin has antiproliferative effects are mediated via targeting Ras/Raf/MAPK signalling pathway, mitochondrial mediated apoptosis, S-phase cell cycle arrest and suppression of cell migration and invasion in human lung carcinoma cells[1][2].

IC50 & Target

IC50: 0.47 μM (tyrosinase);[1] IC50: 22 μM (NCI-H460 cells); 85 μM (MRC-9 cells)[2]
体外研究
(In Vitro)

Norartocarpetin has strong mushroom tyrosinase inhibitory activity with an IC50 value of 0.47 μM[1].
Norartocarpetin (0-100 μM; 48 h) leds to dose-dependent cytotoxic effects in NCI-H460 cells and MRC-9 cells with IC50 values of 22 μM and 85 μM, respectively[2].
Norartocarpetin (0, 11, 22, and 44 μM; 24 h) led to blockade of Ras/Raf/MAPK signalling pathway[2].
Norartocarpetin (0, 11, 22, and 44 μM, 24 h) induced the apoptosis of the human lung carcinoma cells (NCI-H460)[2].
Norartocarpetin (0, 11, 22, and 44 μM) leds to S-phase cell cycle arrest[2].
Norartocarpetin (22 μM; 24 h) leds to dose-dependent suppression of cell invasion[2].
Norartocarpetin (0, 11, 22, and 44 μM, 24 h) leds to significant inhibition of cell migration[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Norartocarpetin 相关抗体:

Cell Viability Assay[2]

Cell Line: MRC-9 (normal fibroblast lung cells) and NCI-H460 (human lung cancer cells)
Concentration: 0, 3.12, 6.25, 12.5, 25, 50, and 100 μM
(first dissolved in DMSO at 1.0 mg/mL and then diluted to different concentrations using DMSO, 30 μL, 20min)
Incubation Time: 48 h
Result: Repressed the viability of NCI-H460 cells in a dose-dependent manner.

Western Blot Analysis[2]

Cell Line: MRC-9 and NCI-H460 cells
Concentration: 0, 11, 22, and 44 μM
Incubation Time: 24 h
Result: Significantly reduced the expression of p-RAS, p-RAF and p-P38 and unchanged the expressions of RAS, RAF and P38.

Apoptosis Analysis[2]

Cell Line: MRC-9 and NCI-H460 cells
Concentration: 0. 11, 22 and 44 μM
Incubation Time: 24 h
Result: Led to dose-dependent apoptosis and induced DNA damage.

Cell Cycle Analysis[2]

Cell Line: MRC-9 and NCI-H460 cells
Concentration: 0, 11, 22, and 44 μM
Incubation Time:
Result: Showed increase of S-phase cells and the percentage of S-phase NCI-H460 LC cells was 30%, 40%, 55% and 70% at 0, 11, 22 and 44 μM concentrations, respectively.

Cell Invasion AssayMRC-9 and NCI-H460 cells

Cell Line: MRC-9 and NCI-H460 cells
Concentration: 22 μM
Incubation Time: 24 h
Result: Significantly reducted (from 100% to about 40%) in the invasion of NCI-H460 human LC cells.

Cell Migration Assay [2]

Cell Line: MRC-9 and NCI-H460 cells
Concentration: 0, 11, 22, and 44 μM
Incubation Time: 24 h
Result: Decreased remarkably the cell invasion in NCI-H460 LC cells in a concentration- dependent manner.
分子量

286.24

Formula

C15H10O6
CAS 号
性状

固体

颜色

White to light yellow

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (349.36 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.4936 mL 17.4679 mL 34.9357 mL
5 mM 0.6987 mL 3.4936 mL 6.9871 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.92%

COA (171 KB) HNMR (222 KB) LCMS (144 KB)

产品使用指南 (1538 KB)
参考文献

Norartocarpetin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4936 mL 17.4679 mL 34.9357 mL 87.3393 mL
5 mM 0.6987 mL 3.4936 mL 6.9871 mL 17.4679 mL
10 mM 0.3494 mL 1.7468 mL 3.4936 mL 8.7339 mL
15 mM 0.2329 mL 1.1645 mL 2.3290 mL 5.8226 mL
20 mM 0.1747 mL 0.8734 mL 1.7468 mL 4.3670 mL
25 mM 0.1397 mL 0.6987 mL 1.3974 mL 3.4936 mL
30 mM 0.1165 mL 0.5823 mL 1.1645 mL 2.9113 mL
40 mM 0.0873 mL 0.4367 mL 0.8734 mL 2.1835 mL
50 mM 0.0699 mL 0.3494 mL 0.6987 mL 1.7468 mL
60 mM 0.0582 mL 0.2911 mL 0.5823 mL 1.4557 mL
80 mM 0.0437 mL 0.2183 mL 0.4367 mL 1.0917 mL
100 mM 0.0349 mL 0.1747 mL 0.3494 mL 0.8734 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Norartocarpetin520-30-9TyrosinaseRasRafMAPKAPK2 (MK2)ApoptosisRaf kinasesMitogen-activated protein kinase activated protein kinase 2MAP kinase activated protein kinase 2MAPK activated protein kinase 2MAPKAP kinase 2tyrosinaseantibrowningNCI-H460 cellsMRC-9 cellslung canceantiproliferativeRas/Raf/MAPK signalingapoptosisS-phase cell cyclemigrationinvasionInhibitorinhibitorinhibit

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