1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Mineralocorticoid Receptor

Mineralocorticoid Receptor

Mineralocorticoid receptor (MR) is a member of the nuclear receptor superfamily and is essential for controlling sodium transport in epithelial tissues such as the kidney and colon.

Mineralocorticoid receptor (MR) is a nuclear receptor (NR) that is critical for controlling sodium and potassium transport in epithelial cells, most notably in the kidney and colon. It also plays important roles in non-epithelial tissues, such as cardiac myocytes, blood vessels, the hippocampus and adipose tissue. The MR is capable of binding multiple classes of steroids with high affinity, including the mineralocorticoids, aldosterone and deoxycorticosterone, the glucocorticoids (GR), cortisol (in humans) or corticosterone (in rodents), and progesterone (PR). While aldosterone is considered the primary physiological MR ligand in humans, in some tissues cortisol may be the primary ligand for MR, whereas PR behaves as a predominant antagonist.

Mineralocorticoid Receptor 相关产品 (10):

Cat. No. Product Name Effect Purity
  • HY-B0251
    Eplerenone Antagonist 99.62%
  • HY-100471
    Esaxerenone Antagonist 99.65%
    Esaxerenone 是一种新型的,高度有效且有选择性的非类固醇盐皮质激素受体拮抗剂。
  • HY-16276
    Osilodrostat Inhibitor 99.04%
    Osilodrostat (LCI699) 是人11β-羟化酶和醛固酮合成酶的有效抑制剂,IC50分别值为2.5 和0.7nM。
  • HY-B1438
    Canrenone Antagonist 99.16%
    Canrenone (Aldadiene; SC9376; SC14266) 是广泛用作利尿剂的醛固酮 (aldosterone) 拮抗剂。
  • HY-B1472
    Deoxycorticosterone acetate Agonist >98.0%
    Deoxycorticosterone 醋酸盐是一种肾上腺皮质素, 作为前体醛固酮。
  • HY-109017
    Vamorolone Antagonist
    Vamorolone (VBP15) 是首创的,具有口服活性的解离性类固醇 (dissociative steroidal) 抗炎药和膜稳定剂。Vamorolone 改善肌营养不良,无副作用。Vamorolone 抑制 (NF-κB) 抑制作用,并降低了激素的影响。
  • HY-B1203A
    Fludrocortisone acetate Agonist 99.45%
    Fludrocortisone acetate (9α-Fludrocortisone acetate) 是一种合成的盐皮质激素, 用于治疗阿狄森氏病工作原理是减少尿液中钠丢失量, 也用于增加血压。
  • HY-109002
    Apararenone Antagonist 98.80%
    Apararenone (MT-3995) 是新型非甾体类盐皮质激素受体 (mineralocorticoid receptor) 拮抗剂,正在开发用于治疗糖尿病性肾病和非酒精性脂肪性肝炎。
  • HY-B1203
    Fludrocortisone Agonist
  • HY-U00200
    Dicirenone Antagonist
    Dicirenone (SC26304) 抑制醛固酮对尿 K+:Na+ 比例的调节作用,也抑制 [3H] 醛固酮与肾细胞质和核受体结合作用。
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