1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Mineralocorticoid Receptor

Mineralocorticoid Receptor (盐皮质激素受体)

Mineralocorticoid receptor (MR) is a member of the nuclear receptor superfamily and is essential for controlling sodium transport in epithelial tissues such as the kidney and colon.

Mineralocorticoid receptor (MR) is a nuclear receptor (NR) that is critical for controlling sodium and potassium transport in epithelial cells, most notably in the kidney and colon. It also plays important roles in non-epithelial tissues, such as cardiac myocytes, blood vessels, the hippocampus and adipose tissue. The MR is capable of binding multiple classes of steroids with high affinity, including the mineralocorticoids, aldosterone and deoxycorticosterone, the glucocorticoids (GR), cortisol (in humans) or corticosterone (in rodents), and progesterone (PR). While aldosterone is considered the primary physiological MR ligand in humans, in some tissues cortisol may be the primary ligand for MR, whereas PR behaves as a predominant antagonist.

Mineralocorticoid Receptor 相关产品 (10):

Cat. No. Product Name Effect Purity
  • HY-B0561
    Spironolactone Antagonist 99.05%
    Spironolactone (SC9420) 是一种具有口服活性醛固酮盐皮质激素受体 (aldosterone mineralocorticoid receptor) 拮抗剂,IC50 值为 24 nM。Spironolactone 也是雄激素受体 (androgen receptor) 拮抗剂,IC50 为 77 nM。Spironolactone 促进足细胞自噬 (autophagy)。
  • HY-B0251
    Eplerenone Antagonist 99.68%
    Eplerenone (Epoxymexrenone) 是一种选择性,竞争性和具有口服活性的醛固酮 (aldosterone) 拮抗剂,IC50 为 138 nM。Eplerenone 对孕酮,雄激素,雌激素和糖皮质激素受体的亲和力低。Eplerenone 可用于高血压和心肌梗死后的心力衰竭的研究。
  • HY-109017
    Vamorolone Antagonist 99.12%
    Vamorolone (VBP15) 是首创的,具有口服活性的解离性类固醇 (dissociative steroidal) 抗炎药和膜稳定剂。Vamorolone 改善肌营养不良,无副作用。Vamorolone 抑制 (NF-κB) 抑制作用,并降低了激素的影响。
  • HY-B1203A
    Fludrocortisone acetate Agonist 99.45%
    Fludrocortisone acetate (9α-Fludrocortisone acetate) 是一种合成的盐皮质激素, 有潜力用于阿狄森氏病的研究,可减少尿液中钠丢失量, 也用于增加血压。
  • HY-B1472
    Deoxycorticosterone acetate Agonist ≥98.0%
    Deoxycorticosterone 醋酸盐是一种肾上腺皮质素, 作为前体醛固酮。
  • HY-B1438
    Canrenone Antagonist 99.16%
    Canrenone (Aldadiene; SC9376; SC14266) 是广泛用作利尿剂的醛固酮 (aldosterone) 拮抗剂。
  • HY-111372
    Finerenone Antagonist 99.75%
    Finerenone (BAY 94-8862) 是第三代选择性、具有口服活性的、非甾体类盐皮质激素受体 (MR) 拮抗剂 (IC50=18 nM)。与糖皮质激素受体 (GR)、雄激素受体 (AR) 和孕酮受体 (AR) 相比,Finerenone 表现出良好的选择性 (>500-fold)。Finerenone 在心肾疾病研究中具有潜在的应用前景,如 2 型糖尿病和慢性肾脏疾病。
  • HY-113151
    18-Oxocortisol Antagonist
    18-Oxocortisol 是由醛固酮合酶 (CYP11B2) 产生的皮质醇衍生物。18-Oxocortisol 是天然存在的盐皮质激素 (mineralocorticoid) 激动剂。18-Oxocortisol 是肾上腺静脉采样中的生物标志物。
  • HY-B1203
    Fludrocortisone Agonist
  • HY-U00200
    Dicirenone Antagonist
    Dicirenone (SC26304) 抑制醛固酮对尿 K+:Na+ 比例的调节作用,也抑制 [3H] 醛固酮与肾细胞质和核受体结合作用。
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