1. Metabolic Enzyme/Protease
  2. Mineralocorticoid Receptor
  3. Apararenone

Apararenone (Synonyms: MT-3995)

目录号: HY-109002 纯度: 98.80%
产品使用指南

Apararenone (MT-3995) 是新型非甾体类盐皮质激素受体 (mineralocorticoid receptor) 拮抗剂,正在开发用于治疗糖尿病性肾病和非酒精性脂肪性肝炎。

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Apararenone Chemical Structure

Apararenone Chemical Structure

CAS No. : 945966-46-1

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Size Price Stock Quantity
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥2145 In-stock
5 mg ¥1950 In-stock
10 mg ¥3150 In-stock
25 mg ¥4580 In-stock
50 mg ¥7800 In-stock
100 mg ¥9500 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

Apararenone (MT-3995) is a novel non-steroidal mineralocorticoid receptor antagonists under development for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.

IC50 & Target

Mineralocorticoid receptor[1]

In Vivo

Recently, a phase II clinical trial has been initiated among patients with non-alcoholic steatohepatitis (NASH) in Japan[1].

Clinical Trial
Molecular Weight

364.39

Formula

C₁₇H₁₇FN₂O₄S

CAS No.

945966-46-1

SMILES

O=C1N(C2=CC=C(F)C=C2)C3=CC=C(NS(C)(=O)=O)C=C3OC1(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (343.04 mM)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7443 mL 13.7216 mL 27.4431 mL
5 mM 0.5489 mL 2.7443 mL 5.4886 mL
10 mM 0.2744 mL 1.3722 mL 2.7443 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。 -80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

ApararenoneMT-3995MT3995MT 3995Mineralocorticoid ReceptorInhibitorinhibitorinhibit

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产品名称:
Apararenone
目录号:
HY-109002
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