1. Signaling Pathways
  2. Neuronal Signaling
  3. Monoamine Oxidase

Monoamine Oxidase

Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. They belong to the protein family of flavin-containing amine oxidoreductases. Monoamine oxidases catalyze the oxidative deamination of monoamines. Oxygen is used to remove an amine group from a molecule, resulting in the corresponding aldehyde and ammonia. Monoamine oxidases contain the covalently bound cofactor FAD and are, thus, classified as flavoproteins. Because of the vital role that MAOs play in the inactivation of neurotransmitters, MAO dysfunction is thought to be responsible for a number of psychiatric and neurological disorders. MAO-A inhibitors act as antidepressant and antianxiety agents, whereas MAO-B inhibitors are used alone or in combination to treat Alzheimer’sand Parkinson’s diseases.

Monoamine Oxidase 相关产品 (42):

Cat. No. Product Name Effect Purity
  • HY-B1018A
    Phenelzine sulfate Inhibitor 98.70%
    Phenelzine硫酸盐是一种非选择性和不可逆的单胺氧化酶抑制剂 (MAOI), 用作抗抑郁药和抗焦虑药。
  • HY-B1496
    Tranylcypromine hemisulfate Inhibitor 99.05%
    Tranylcypromine hemisulfate是一种用于治疗抑郁症的不可逆,非选择性 MAO 抑制剂。
  • HY-100546A
    GSK-LSD1 Dihydrochloride Inhibitor >98.0%
    GSK-LSD1 Dihydrochloride是有效,选择性,不可逆的赖氨酸特异性脱甲基酶 (LSD1) 抑制剂,IC50 值为16 nM。
  • HY-N0529
    Rosmarinic acid Inhibitor 99.06%
    迷迭香酸 (Rosmarinic acid) 是一种天然多酚物质,具有抗氧化、抗炎活性。
  • HY-A0091
    Pargyline hydrochloride Inhibitor 99.91%
  • HY-14196
    Toloxatone Inhibitor 99.34%
    Toloxatone (MD 69276) 是一种可逆的单胺氧化酶 A (MAOA) 抑制剂。用作抗抑郁剂。
  • HY-14197A
    Clorgyline hydrochloride Inhibitor 99.53%
    Clorgyline hydrochloride 是不可逆的,选择性单胺氧化酶A(MAO-A)抑制剂,结构上与Pargyline相关。
  • HY-14605
    Rasagiline mesylate Inhibitor
    Rasagiline mesylate 是MAO-B抑制剂,可作用于原发性帕金森病。
  • HY-16677A
    Mofegiline hydrochloride Inhibitor
    Mofegiline hydrochloride (MDL72974A) 是酶活化的不可逆MAO-B抑制剂,对MAO-A和MAO-B的IC50分别为680和3.6 nM。
  • HY-N0159
    Paeonol Inhibitor 99.98%
    Paeonol 是牡丹根的活性提取物,Paeonol 抑制 MAO-AMAO-BIC50 分别为 54.6 μM 和 42.5 μM。
  • HY-B0884A
    Minaprine dihydrochloride Inhibitor 99.61%
    Minaprine dihydrochloride 是单胺氧化酶 MAO-A 可逆性抑制剂,还对乙酰胆碱酯酶有微弱抑制,抗抑郁类化合物。
  • HY-70057
    Safinamide Inhibitor 99.77%
    Safinamide (EMD 1195686; FCE 26743)是可逆的MAO-B抑制剂,IC50为98 nM,比对MAO-A的抑制性高5918倍。
  • HY-B0886
    Iproniazid phosphate Inhibitor 99.92%
    Iproniazid phosphate 是一种非选择性的,不可逆的单胺氧化酶抑制剂 (MAOI)。
  • HY-B1199
    Nialamide Inhibitor
    Nialamide是一种非选择性的, 不可逆的单胺氧化酶抑制剂 (MAOI), 用作抗抑郁药。
  • HY-B0534
    Moclobemide Inhibitor 99.45%
    Moclobemide(Ro111163)是可逆的单胺氧化酶(MAO)抑制剂,IC50为6.1 μM,可作用于重度抑郁症。
  • HY-B0884
    Minaprine Inhibitor
  • HY-100027A
    Ro 41-1049 hydrochloride Inhibitor 99.96%
    Ro 41-1049 hydrochloride 是一种可逆的并具有选择性的 monoamine oxidase-A (MAO-A) 抑制剂。在人额叶皮层和胎盘的膜制剂中发现了[3H]Ro 41-1049 的高亲和力结合位点的同质群体 (Kd 值分别为 16.5 和 64.4 nM)。
  • HY-14200
    (S)-Rasagiline Inhibitor 99.60%
    (S)-Rasagiline (TVP1022) 是 Rasagiline 的 S 型同分异构体。
  • HY-N2336
    Rosmarinic acid racemate Inhibitor 98.01%
    Rosmarinic acid racemate是Rosmarinic acid的外消旋体。Rosmarinic acid抑制MAO-A, MAO-BCOMT酶,IC50分别为50.1, 184.6 和26.7 μM。
  • HY-13929
    Isocarboxazid Inhibitor >98.0%
    Isocarboxazid 是一种非选择性的、不可逆的单胺氧化酶 monoamine oxidase 抑制剂,其在大鼠大脑中测得的 IC50 值为4.8 μM。
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