2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Opioid Receptor

Opioid Receptor

Opioid Receptor

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Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.

Opioid Receptor 相关产品 (76):

Cat. No. Product Name Effect Purity
  • HY-12745A
    Nalfurafine hydrochloride Agonist 99.93%
    Nalfurafine hydrochloride是一种κ-opioid激动剂，是日本批准的抗瘙痒药物。
  • HY-B0418A
    Loperamide hydrochloride Agonist 99.69%
    Loperamide (hydrochloride) (R-18553 (hydrochloride)) 是用于治疗腹泻的阿片受体 (opioid receptor) 激动剂。
  • HY-101386
    PZM21 Agonist 99.45%
    PZM21是高效选择性的μ opioid receptor受体激动剂，EC50值为1.8 nM。
  • HY-13044
    ADL-5859 Agonist 99.65%
    ADL5859是δ-阿片受体选择性激动剂，Ki为0.8 nM，对hERG有弱抑制性。
  • HY-P0210
    DAMGO Agonist 98.10%
    DAMGO 是 一种选择性的 μ-阿片受体 (μ-OPR) 激动剂，Kd 值为 3.46 nM。
  • HY-123534
    CYT-1010 Agonist 99.74%
    CYT-1010 是一种 mu-阿片受体激动剂，影响 beta-arrestin 的募集和 cAMP 生产抑制，EC50 值分别为 13.1 nM、0.0053 nM，详细信息请参考专利文献 WO2013173730A2。
  • HY-P1467A
    [Met5]-Enkephalin, amide TFA Agonist 99.71%
    [Met5]-Enkephalin, amide TFA 是一种 δ 和 ζ 阿片受体 (opioid receptor) 激动剂。
  • HY-G0021
    N-Desmethylclozapine Agonist 98.66%
    N-Desmethylclozapine 是登革病毒抑制剂，同时为 δ-opioid 受体的激动剂。
  • HY-N0164
    Matrine Agonist >98.0%
    Matrine (Matridin-15-one) 是来源于植物的生物碱，有抗肿瘤活性，是kappa阿片受体激动剂。
  • HY-101177
    Naltrindole hydrochloride Antagonist 99.68%
    Naltrindole hydrochloride是高效，选择性的非多肽类 δ opioid 受体拮抗剂，Ki值为0.02 nM。
  • HY-10487
    JDTic dihydrochloride Antagonist 99.79%
    JDTic dihydrochloride 是一种有效的 kappa-opioid receptors (KOR) 的拮抗剂，常用于神经系统疾病的研究。
  • HY-16655A
    Oliceridine hydrochloride Agonist 98.79%
    Oliceridine hydrochloride (TRV130 hydrochloride) 是新颖的 MOR 激动剂，能够优先激活 G-protein 信号通路，而对 β-arrestin 的作用稍弱。
  • HY-15122A
    Sinomenine hydrochloride Activator >98.0%
    Sinomenine hydrochloride 是 NF-κB 活化的阻断剂，也是 μ 阿片受体 (μ-opioid receptor) 的激活剂。
  • HY-101718
    Aticaprant Antagonist 99.24%
    Aticaprant (CERC-501) 是一种有效地可渗透中枢神经的kappa opioid受体拮抗剂，Ki值为0.807 nM。
  • HY-15536
    Cebranopadol Agonist 98.76%
    Cebranopadol 是NOP 和 opioid receptor 激动剂，作用于人NOP，MOP，KOP 和δ-阿片肽(DOP)受体，Ki/EC50 分别为 0.9 nM/13 nM，0.7 nM/1.2 nM，2.6 nM/17 nM，18 nM/110 nM。
  • HY-P0288
    [Leu5]-Enkephalin Agonist 99.72%
    [Leu5]-Enkephalin 是一种具有吗啡药性的五肽。作为阿片受体 (opioid receptors) 激动剂。
  • HY-13274
    JTC-801 Antagonist 99.73%
    JTC-801 是一种具有选择性的 opioid receptor-like1 (ORL1) receptor 抑制剂，其 Ki 值为 8.2 nM。
  • HY-P0183
    Nociceptin Agonist 99.79%
    Nociceptin 是一种十七肽，为 nociceptin 受体的内源性配体，具有镇痛作用。
  • HY-13222
    BAN ORL 24 Antagonist
    BAN ORL 24是NOP受体拮抗剂，对NOP，κ-，μ-和δ-受体的IC50分别为0.27，2500，6700和> 10000 nM。
  • HY-111454
    SR17018 Agonist >98.0%
    SR17018 是一种 mu 型阿片受体 (mu-opioid-receptor) 激动剂，能够与 GTPγS 结合，EC50 值为 97 nM。
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