β-Endorphin, human  (Synonyms: β-内啡肽,人)

β-Endorphin, human, a prominent endogenous peptide, existing in the hypophysis cerebri and hypothalamus, is an agonist of opioid receptor, with preferred affinity for μ-opioid receptor and δ-opioid receptor; β-Endorphin, human exhibits antinociception activity.

β-Endorphin, human 是阿片受体激动剂，对 μ-阿片受体和 δ-阿片受体具有优先亲和力。β-Endorphin, human 通过刺激 ε-阿片受体 (而非 μ-、δ- 和 κ-阿片受体) 发挥抗伤害活性^[1]。
β-Endorphin, human 具有抗伤害活性。首先，在痛觉过敏时，β-Endorphin, human 会与阿片受体结合。此外，β-Endorphin, human 还能抑制脊髓水平 P 物质的释放，并阻断疼痛在初级感觉神经元上的传导。此外，β-Endorphin, human 还能激活位于中枢神经系统的内源性镇痛系统。此外，β-Endorphin, human 还能抑制疼痛的传导和伤害感受器的激动，从而发挥镇痛作用^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

3464.98

C₁₅₈H₂₅₁N₃₉O₄₆S

61214-51-5

固体

White to off-white

Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu

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β-内啡肽,人

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

• [1]. Narita M, et al. Evidence for the existence of the beta-endorphin-sensitive "epsilon-opioid receptor" in the brain: the mechanisms of epsilon-mediated antinociception. Jpn J Pharmacol. 1998 Mar;76(3):233-53.  [Content Brief]

  [2]. Luan YH, et al. Action of β-endorphin and nonsteroidal anti-inflammatory drugs, and the possible effects of nonsteroidal anti-inflammatory drugs on β-endorphin. J Clin Anesth. 2017 Feb;37:123-128.  [Content Brief]