1. Signaling Pathways
  2. GPCR/G Protein
  3. Oxytocin Receptor

Oxytocin Receptor

Oxytocin, a hormone involved in numerous physiologic processes, plays a central role in the mechanisms of parturition and lactation. It acts through its receptor, which is a transmembrane receptor belonging to the rhodopsin-type class I G-protein-coupled receptor (GPCR) superfamily, while Gq/phospholipase C (PLC)/inositol 1,4,5-triphosphate (InsP3) is the main pathway via which it exerts its action in the myometrium. The main signaling pathway is the Gq/LPC/Ins3 pathway, but the MAPK and the RhoA/Rho kinase pathways are also activated, contributing to increased prostaglandin production and direct contractile effect on myometrial cells. Various peptide and nonpeptide antagonists have been developed as potential tocolytic agents or research tools for the various Oxytocin functions. Many of these oxytocin receptor antagonists are used only as pharmacological tools, while others have tocolytic action.

Oxytocin Receptor 相关产品 (17):

Cat. No. Product Name Effect Purity
  • HY-17571A
    Oxytocin acetate Agonist 99.79%
    Oxytocin acetate (α-Hypophamine acetate) 是哺乳动物神经垂体荷尔蒙,作用于催产素受体。
  • HY-17572
    Atosiban Antagonist 99.09%
    Atosiban(RW22164; Tractocile)为九肽,是desamino-oxytocin类似物,是竞争性加压素/催产素受体拮抗剂,能抑制催产素介导的三磷酸肌醇从子宫肌层细胞膜上释放。
  • HY-15023
    Cligosiban Antagonist 99.85%
    Cligosiban (PF-3274167) 是一种口服生物利用度高、脑渗透性好的非肽催产素受体拮抗剂,与加压素受体相比具有很好的选择性,对 V1b 和 V1a 亚型几乎没有亲和力。Cligosiban 抑制啮齿类动物的射精生理。
  • HY-108677
    L-368,899 hydrochloride Antagonist 98.00%
    L-368,899 hydrochloride 是一种有效的,选择性的,可口服的,非肽类催产素受体 oxytocin receptor 拮抗剂,对大鼠和人子宫 oxytocin receptorIC50 值分别为 8.9 nM 和 26 nM,为抗早产剂。
  • HY-17573
    Carbetocin Agonist >98.0%
    Carbetocin (Lonactene; Duratocin)是外周催产素受体激动剂,能控制产后出血。
  • HY-124733A
    LIT-001 Agonist 98.52%
    LIT-001 是第一种非肽类催产素受体 (OT-R) 激动剂 (EC50=55 nM; Ki=226 nM)。LIT-001 改善孤独症小鼠模型的社交互动。
  • HY-124733
    LIT-001 free base Agonist
    LIT-001 free base 是第一种非肽类催产素受体 (OT-R) 激动剂 (EC50=55 nM; Ki=226 nM)。LIT-001 free base 改善孤独症小鼠模型的社交互动。
  • HY-15015
    OT-R antagonist 1 Antagonist >98.0%
    OT-R antagonist 1是一种新型有效的选择性非肽类OT-R拮抗剂, 抑制催产素诱发的细胞内Ca2+活动(IC50=8nM)。
  • HY-17571
    Oxytocin Agonist 98.68%
    Oxytocin (α-Hypophamine)是哺乳动物神经脑垂体激素,能特异地与催产素受体高亲和性结合。
  • HY-15015A
    OT-R antagonist 2 Antagonist 99.74%
    OT-R antagonist 2是一种非肽类OT-R拮抗剂, 抑制大鼠催产素受体(IC50 = 0.33 μM)。
  • HY-128351
    SHR1653 Antagonist
    SHR1653是强效的、选择性的、能透过大脑的催产素受体 (OTR) 的拮抗剂,对hOTR 的 IC50 值为 15 nM。
  • HY-14778
    Retosiban Antagonist
    Retosiban (GSK221149A) 是有效,选择性的催产素 (oxytocin) 拮抗剂, Ki值为0.65 nM。
  • HY-15010
    L-371,257 Antagonist >99.0%
    L-371,257 是一种口服生物有效的,不能透过血脑屏障的,竞争性的,选择性催产素受体 (oxytocin receptor) 拮抗剂 (pA2=8.4),对催产素受体 (Ki=19 nM) 和血管加压素 V1a 受体 (vasopressin V1a receptorKi=3.7 nM) 具有高亲和力。
  • HY-103649
    OT antagonist 3 Antagonist
    OT antagonist 3 是一种催产素 (oxytocin, OT) 拮抗剂,详细信息请参考专利文献 WO2007017752A1。
  • HY-103651
    OT antagonist 1 demethyl derivative Antagonist
    OT antagonist 1 demethyl derivative 是 OT antagonist 1 的去甲基化产物. OT antagonist 1 (Compound 4) 是一种有效的选择性催产素 (Oxytocin) 拮抗剂,Ki 为 50 nM。
  • HY-105018
    Epelsiban Antagonist
    Epelsiban (GSK 557296) 是一种有效的,选择性的,可口服的催产素受体 (oxytocin receptor) 抑制剂,对人催产素受体的 pKi 值为 9.9。
  • HY-103650
    OT antagonist 1 Antagonist
    OT antagonist 1 (Compound 4) 是一种有效的选择性催产素 (Oxytocin) 拮抗剂,Ki 为 50 nM。
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