1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. RAD51

RAD51

RAD51 protein family assist in repair of DNA double strand breaks. RAD51 family members are homologous to the bacterial RecA and yeast Rad51. In humans, RAD51 is a 339-amino acid protein that plays a major role in homologous recombination of DNA during double strand break repair. RAD51 is involved in the search for homology and strand pairing stages of the process. RAD51 can interact with the ssDNA-binding protein RPA, BRCA2, PALB2 and RAD52. Recent studies using fluorescent labeled Rad5 has indicated that Rad51 fragments elongate via multiple nucleation events followed by growth, with the total fragment terminating when it reaches about 2 μm in length.

RAD51 相关产品 (8):

Cat. No. Product Name Effect Purity
  • HY-101462
    RAD51 Inhibitor B02 Inhibitor 99.87%
    RAD51 Inhibitor B02 (B02)是人RAD51的抑制剂,IC50值为27.4 μM。
  • HY-19793
    RS-1 Activator 99.55%
    RS-1 是一种 RAD51 的激活剂,同时可增强 CRISPR/Cas9 的活性。
  • HY-15317
    RI-1 Inhibitor 99.30%
    RI-1是RAD51抑制剂,IC50在5到30 μM之间。
  • HY-10206
    Amuvatinib Inhibitor 99.36%
    Amuvatinib (MP470) 是一种多靶点酪氨酸激酶抑制剂,对突变 c-KitPDGFRαFlt3c-Metc-Ret 具有有效活性。Amuvatinib (MP470) 还是一种 DNA 修复抑制剂,靶向蛋白 DNA 修复 RAD51,从而破坏 DNA 损伤修复。具有抗肿瘤活性。
  • HY-103710
    IBR2 Inhibitor 98.14%
    IBR2 是一种特异性 RAD51 抑制剂。
  • HY-16904
    RI-2 Inhibitor 99.22%
    RI-2 是一种可逆的 RAD51 抑制剂,IC50 值为 44.17 μM,能够特异性地抑制人体细胞中的同源重组修复。
  • HY-10206A
    Amuvatinib hydrochloride Inhibitor
    Amuvatinib hydrochloride (MP470 hydrochloride) 是一种多靶点酪氨酸激酶抑制剂,对突变 c-KitPDGFRαFlt3c-Metc-Ret 具有有效活性。Amuvatinib hydrochloride (MP470 hydrochloride) 还是一种 DNA 修复抑制剂,靶向蛋白 DNA 修复 RAD51,从而破坏 DNA 损伤修复。具有抗肿瘤活性。
  • HY-111887
    RAD51-IN-2 Inhibitor
    RAD51-IN-2 (化合物 example 67A) 是一种 RAD51 抑制剂,详细信息请参考专利文献 WO2019/051465A1。
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