1. Signaling Pathways
  2. Metabolic Enzyme/Protease
    Vitamin D Related/Nuclear Receptor
  3. RAR/RXR

RAR/RXR (维甲酸受体)

Retinoic acid receptors; Retinoid X receptors

核视黄酸受体 (RAR) 是转录转录调节因子,控制特定基因亚群的表达,随后与配体结合并严格控制磷酸化过程。RAR 包括三种亚型,α (NR1B1)、β (NR1B2) 和 γ (NR1B3),由不同的基因编码。RAR 用作配体依赖性转录调节因子,与类视黄酸 X 受体 (RXR) 异二聚化,后者也包括三种类型,α NR2B1、β (NR2B2) 和 γ (NR2B3)。RAR 在多种生物过程中发挥关键作用,包括发育、生殖、免疫、器官形成和体内平衡,如在小鼠中进行的维生素 A 缺乏症 (VAD)、药理学和遗传学研究所评估的那样。

类视黄酸 X 受体 (RXR) 属于配体激活转录因子家族,可调节后生动物生活的许多方面。一类核受体需要 RXR 作为异二聚化伙伴才能发挥作用。

The nuclear retinoic acid receptors (RARs) are transcriptional transregulators, which control the expression of specific gene subsets subsequently to ligand binding and to strictly controlled phosphorylation processes. RARs consist of three subtypes, α (NR1B1), β (NR1B2) and γ (NR1B3), encoded by separate genes. RARs function as ligand-dependent transcriptional regulators, heterodimerized with retinoid X receptors (RXRs), which also consist of three types, α NR2B1, β (NR2B2) and γ (NR2B3). RARs play critical roles in a variety of biological processes, including development, reproduction, immunity, organogenesis and homeostasis, as assessed by vitamin A-deficiency (VAD), pharmacological and genetic studies conducted in the mouse.

Retinoid X receptor (RXR) belongs to a family of ligand-activated transcription factors that regulate many aspects of metazoan life. A class of nuclear receptors requires RXR as heterodimerization partner for their function.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-14531R
    Talarozole (Standard)

    他拉罗唑 (Standard)

    Inhibitor
    Talarozole (Standard) 是 Talarozole 的分析标准品。本产品用于研究及分析应用。Talarozole (R115866) 是一种口服性全反式维甲酸代谢阻断剂 (RAMBA),可提高内源性全反式维甲酸 (RA) 的细胞内水平。Talarozole 抑制 CYP26A1CYP26B1IC50 值分别为 5.4 和 0.46 nM。
    Talarozole (Standard)
  • HY-14171S2
    Bexarotene-13C6 Agonist
    Bexarotene-13C6 (LGD1069-13C6) 是 13C 标记的 Bexarotene. Bexarotene (LGD1069) 是一种高亲和力的选择性类视黄醇 X 受体 (RXR) 激动剂,对 RXRαRXRβRXRγEC50 分别为 33、24、25 nM。Bexarotene 对 RAR 受体的亲和力有限 (EC50 >10000 nM)。Bexarotene 可用于皮肤 T 细胞淋巴瘤的研究。
    Bexarotene-<sup>13</sup>C<sub>6</sub>
  • HY-107218
    11-Hydroxysugiol

    11-羟基柳杉酚

    Modulator
    11-Hydroxysugiol 通过调节 RARα 和维生素 D3 受体 (VDR) 来调节细胞内受体的 SUMOylation。
    11-Hydroxysugiol
  • HY-14802C
    (+)-Talarozole Inhibitor 99.28%
    (+)-Talarozole 是视黄酸代谢的有效抑制剂,来自专利 WO 1997049704 A1。
    (+)-Talarozole
  • HY-111843
    Ch55-O-C3-NH2
    Ch55-O-C3-NH2 (RAR ligand 1) 是一种基于 Ch 55 的配体,靶向作用于 RAR。Ch55-O-C3-NH2 (RAR ligand 1) 通过 linker 与 cIAP1 配体 Bestatin 结合从而形成 SNIPER
    Ch55-O-C3-NH2
目录号 产品名 / 同用名 应用 反应物种

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