1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. SRPK

SRPK (富丝氨酸/精氨酸蛋白激酶)

Serine-arginine protein kinases

SRPKs is a critical enzyme family that regulates splicing activity in the cell. The first serine-arginine (SR) protein kinase identified is SRPK1, which is isolated from mitotic cells, and it is described to phosphorylate SR proteins and to promote their release from nuclear speckles during the G2/M phase of the cell cycle. SRPK1 is the prototype of the SRPK family, which also includes the two homologous SRPK2 and SRPK3 proteins. SRPKs are characterized by a bipartite catalytic domain separated by a unique spacer sequence and are mainly localized in the cytoplasm of mammalian cells.

SRPKs can translocate into the nucleus of cells under several conditions, such as during the G2/M phase of the cell cycle, or after osmotic stress, or as a consequence of activation of the epidermal growth factor (EGF) signal transduction pathway.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-117661
    SPHINX31 Inhibitor 99.13%
    SPHINX31 是一种有效的、丝氨酸/富含精氨酸的蛋白激酶1 (SRPK1) 的选择性抑制剂,其IC50 值为 5.9 nM。SPHINX31 能够抑制富丝氨酸/精氨酸剪接因子 1 (SRSF1) 的磷酸化。SPHINX31 还能降低促血管生成基因 VEGF-A165a 亚型的 mRNA 表达。SPHINX31 可用于研究新生血管性眼病。
  • HY-13949
    SRPIN340 Inhibitor 99.97%
    SRPIN340 是一种 ATP 竞争性的 SRPK抑制剂,能够抑制 SRPK1 的活性,Ki 值为 0.89 μM。
  • HY-116856
    SRPKIN-1 Inhibitor 98.02%
    SRPKIN-1是共价,不可逆的 SRPK1/2 抑制剂,IC50 分别为35.6 和 98 nM。有抗血管生成作用。
  • HY-148518
    MSC-1186 Inhibitor 99.42%
    MSC-1186 是一种高选择性的泛 SRPK 抑制剂。MSC-1186 对 SRPK1、SRPK2 和 SRPK3 具有活性,IC50 值分别为 2.7 nM、81 nM 和 0.6 nM。MSC-1186 可用于癌症研究。
  • HY-114653
    SRPIN803 Inhibitor 99.17%
    SRPIN803 是一种有效的 CK2SRPK1 双重抑制剂,IC50 分别为 203 nM 和 2.4 μM。SRPIN803 具有抗血管生成活性。SRPIN803 可用于年龄相关性黄斑变性的研究。
  • HY-160586
    Srpk1-IN-1 Inhibitor
    Srpk1-IN-1 (compound 12) 是 SRPK1 的有效抑制剂,IC50 为 0.3 nM。
  • HY-160587
    Antiangiogenic agent 5 Inhibitor
    Antiangiogenic agent 5 (compound 17) 具有抗血管生成活性。Antiangiogenic agent 5 对 SRPK1 具有抑制作用,IC50 为 1.3 nM。
    Antiangiogenic agent 5
  • HY-132126
    SPHINX Inhibitor 99.87%
    SPHINX 是 SRPK1 的选择性抑制剂,IC50 值为 0.58 μM。SPHINX 有效地减少体内脉络膜新生血管 (CNV)。SPHINX 可用于老年性黄斑变性的研究。
  • HY-113831
    CLK1/2-IN-3 Inhibitor
    CLK1/2-IN-3 (compound 3) 是一种有效的选择性 CLK1CLK2 抑制剂,CLK1、CLK2、SRPK1、SRPK2、SRPK3 的 IC50 值分别为 1.1、2.1、130、260、260 nM。CLK1/2-IN-3 显示出抗增殖活性。CLK1/2-IN-3 降低内源性磷酸化 SR 蛋白的水平并增加 S6K mRNA 的表达。
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