2. Cell Cycle/DNA Damage
  3. SRPK
  4. SPHINX

SPHINX 是 SRPK1 的选择性抑制剂，IC50 值为 0.58 μM。SPHINX 有效地减少体内脉络膜新生血管 (CNV)。SPHINX 可用于老年性黄斑变性的研究。

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SPHINX Chemical Structure

SPHINX Chemical Structure

CAS No. : 848057-98-7

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥3080
In-stock
1 mg ￥1120
In-stock
5 mg ￥2800
In-stock
10 mg ￥4200
In-stock
25 mg ￥7800
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

SPHINX 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SPHINX is a selective SRPK1 inhibitor with an IC50 value of 0.58 μM. SPHINX effectively reduces Choroidal Neovascularization (CNV) in vivo. SPHINX can be used for the research of (age-related macular degenaration) AMD[1].

IC50 & Target

IC50: 0.58 μM (SRPK1)[1]
体外研究
(In Vitro)

SPHINX (10 μM; 2 h) affects EGF-induced phosphorylation of SRSF1 and SRSF2[1].
SPHINX (5 μM; 24 h) reduces the expression of VEGF165 relative to GAPDH control either in primary RPE and ARPE-19 cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SPHINX 相关抗体:

Western Blot Analysis[1]

Cell Line: ARPE-19 cell line
Concentration: 10 μM
Incubation Time: 2 hours
Result: Blocked EGF-induced phosphorylation of SRSF1 and SRSF2.
体内研究
(In Vivo)

SPHINX (10 ng; i.o. on laser photocoagulation day 0 and day 7) affects neovascular growth in vivo[1].
SPHINX (25 ng; i.o. on laser photocoagulation day 0 and day 7) affects the CNV area in CNV rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57/B6 mice with laser-induced CNV[1]
Dosage: 10 ng
Administration: Intraocular injection; 10 ng on laser photocoagulation day 0 and day 7
Result: Significantly reduced neovascular growth compared with saline-injected controls.
Animal Model: Norway Brown rats with laser-induced choroidal neovascularization[1]
Dosage: 25 ng (10 ng/uL)
Administration: Intraocular injection; 25 ng (10 ng/uL) on laser photocoagulation day 0 and day 7
Result: Significantly reduced the CNV area compared with saline injected controls.
Clinical Trial
分子量

354.32

Formula

C17H17F3N2O3
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 50 mg/mL (141.12 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8223 mL 14.1115 mL 28.2231 mL
5 mM 0.5645 mL 2.8223 mL 5.6446 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

SPHINX 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8223 mL 14.1115 mL 28.2231 mL 70.5577 mL
5 mM 0.5645 mL 2.8223 mL 5.6446 mL 14.1115 mL
10 mM 0.2822 mL 1.4112 mL 2.8223 mL 7.0558 mL
15 mM 0.1882 mL 0.9408 mL 1.8815 mL 4.7038 mL
20 mM 0.1411 mL 0.7056 mL 1.4112 mL 3.5279 mL
25 mM 0.1129 mL 0.5645 mL 1.1289 mL 2.8223 mL
30 mM 0.0941 mL 0.4704 mL 0.9408 mL 2.3519 mL
40 mM 0.0706 mL 0.3528 mL 0.7056 mL 1.7639 mL
50 mM 0.0564 mL 0.2822 mL 0.5645 mL 1.4112 mL
60 mM 0.0470 mL 0.2352 mL 0.4704 mL 1.1760 mL
80 mM 0.0353 mL 0.1764 mL 0.3528 mL 0.8820 mL
100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.7056 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SPHINX848057-98-7SRPKSerine-arginine protein kinasesscaffoldSRSFEGFphosphorylationGAPDHsmall moleculeVEGFmiceratAMDInhibitorinhibitorinhibit

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目录号：
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