1. Signaling Pathways
  2. Neuronal Signaling
  3. Serotonin Transporter

Serotonin Transporter

Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.

Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.

Serotonin Transporter 相关产品 (47):

Cat. No. Product Name Effect Purity
  • HY-B0102A
    Fluoxetine hydrochloride Inhibitor 99.84%
    Fluoxetine hydrochloride是抗抑郁药和选择性的血清素重吸收抑制剂。
  • HY-42110
    Deschloroclozapine Antagonist 99.79%
    Deschloroclozapine 是 dopamineserotonin 受体拮抗剂,对多巴胺D1,D2,D4和血清素 S2A,S2C,S3的 Ki 值分别为200,2500,420,39,84,40 nM。
  • HY-B0492
    Paroxetine hydrochloride Inhibitor >99.0%
    Paroxetine hydrochloride 是一种抗抑郁药,为高效的五羟色胺再摄取抑制剂,能抑制 GRK2 活性,IC50 值为 14 μM。
  • HY-B1272
    Desipramine hydrochloride Inhibitor 99.68%
    Desipramine hydrochloride 是去甲肾上腺素转运蛋白 (NET), 5-羟色胺转运体 (SERT) 和多巴胺转运 (DAT) 的抑制剂,其 Ki 值分别为 4, 61 和 78,720 nM。
  • HY-B0103A
    Fluvoxamine maleate Inhibitor 99.85%
    Fluvoxamine (maleate) (DU-23000 (maleate)) 是5-羟色胺再吸收抑制剂,有抗抑郁活性。
  • HY-B0457S
    Clomipramine D3 hydrochloride Inhibitor
    Clomipramine D3 hydrochloride 是一种氘标记的 Clomipramine hydrochloride。Clomipramine hydrochloride 是 5-羟色胺转运体 (SERT)、去甲肾上腺素转运体 (NET) 和多巴胺转运体 (DAT) 阻断剂,Ki 分别为 0.14,54 和 3 nM。
  • HY-B0161AS
    Duloxetine D3 hydrochloride Inhibitor
    Duloxetine D3 hydrochloride ((S)-Duloxetine D3 hydrochloride) 是 Duloxetine hydrochloride 的氘代物。Duloxetine hydrochloride 是 5-羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂 (SNRI),Ki 为 4.6 nM,可作用于广泛性焦虑症。
  • HY-15414S
    Vortioxetine D8 Inhibitor
    Vortioxetine D8 是氘代标记的Vortioxetine。Vortioxetine 是 5-HT1A,5-HT1B,5-HT3A,5-HT7 受体 和 5-羟色胺转运体 (SERT) 的抑制剂,其 Ki 值分别为 15 nM,33 nM,3.7 nM,19 nM 和 1.6 nM。
  • HY-B1490
    Imipramine hydrochloride Inhibitor 99.93%
    Imipramine hydrochloride抑制血清素转运蛋白(serotonin),体内试验的IC50值为32 nM。
  • HY-B0176A
    Sertraline hydrochloride Inhibitor 99.90%
  • HY-14258A
    Escitalopram oxalate Inhibitor 99.98%
    Escitalopram oxalate ((S)-(+)Citalopram oxalate) 是选择性5羟色胺重吸收抑制剂(SSRI),Ki为0.89 nM。
  • HY-B1287
    Citalopram hydrobromide Inhibitor >99.0%
    Citalopram盐酸盐是选择性的血清素再摄取抑制剂 (SSRI) 类的抗抑郁药, 已被FDA批准用于治疗抑郁症。
  • HY-B0161A
    Duloxetine hydrochloride Inhibitor 99.92%
    Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) 是 5-羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂 (SNRI),Ki 为 4.6 nM,可作用于广泛性焦虑症。
  • HY-B0457
    Clomipramine hydrochloride Inhibitor 99.72%
    Clomipramine hydrochloride 是5-羟色胺转运体 (SERT)、去甲肾上腺素转运体 (NET) 和多巴胺转运体 (DAT) 阻断剂,Ki 分别为 0.14,54 和 3 nM。
  • HY-B0168A
    Milnacipran hydrochloride Inhibitor 99.87%
  • HY-B0602A
    Desvenlafaxine succinate hydrate Inhibitor 99.76%
  • HY-15414
    Vortioxetine Inhibitor 98.81%
    Vortioxetine 是 5-HT1A,5-HT1B,5-HT3A,5-HT7 受体 和 5-羟色胺转运体 (SERT) 的抑制剂,其 Ki 值分别为 15 nM,33 nM,3.7 nM,19 nM 和 1.6 nM。
  • HY-15414A
    Vortioxetine hydrobromide Inhibitor 99.94%
    Vortioxetine hydrobromide 是5-HT1A,5-HT1B,5-HT3A,5-HT7 受体 和5-羟色胺转运体 (SERT) 的抑制剂,其Ki值分别为 15 nM,33 nM,3.7 nM,19 nM 和 1.6 nM。
  • HY-14261
    Vilazodone Hydrochloride Inhibitor 99.95%
    Vilazodone Hydrochloride (EMD 68843 Hydrochloride) 是 5-羟色胺转运体 (SER) 的抑制剂和 5-HT1A 受体的部分激动剂。
  • HY-B0196A
    Venlafaxine hydrochloride Inhibitor 99.87%
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