1. Signaling Pathways
  2. Neuronal Signaling
  3. Serotonin Transporter

Serotonin Transporter

Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.

Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.

Serotonin Transporter 相关产品 (44):

Cat. No. Product Name Effect Purity
  • HY-B0102A
    Fluoxetine hydrochloride Inhibitor 99.86%
    Fluoxetine hydrochloride是抗抑郁药和选择性的血清素重吸收抑制剂。
  • HY-42110
    Dopamine serotonin antagonist-1 Antagonist 99.79%
    Dopamine serotonin antagonist-1是 dopamineserotonin 受体拮抗剂,对多巴胺D1,D2,D4和血清素S2A,S2C,S3的 Ki 值分别为200,2500,420,39,84,40 nM。
  • HY-B0492
    Paroxetine hydrochloride Inhibitor >99.0%
    Paroxetine hydrochloride 是一种抗抑郁药,为高效的五羟色胺再摄取抑制剂,能抑制 GRK2 活性,IC50 值为 14 μM。
  • HY-B0103A
    Fluvoxamine maleate Inhibitor 99.85%
    Fluvoxamine (maleate) (DU-23000 (maleate)) 是5-羟色胺再吸收抑制剂,有抗抑郁活性。
  • HY-B0176A
    Sertraline hydrochloride Inhibitor 99.90%
    Sertraline盐酸盐是选择性5羟色胺再吸收抑制剂(SSRI)。
  • HY-18332C
    DOV-216,303 Free Base Inhibitor 98.47%
    DOV-216,303 (Free Base) 是有效的 5-羟色胺、去甲肾上腺素、多巴胺再摄取的三重抑制剂,其对 hSERT、hNET 和 hDAT 的 IC50 值分别为 14 nM,20 nM和78 nM。在嗅球切除大鼠模型中,可增加前额皮质中单胺的释放及具有抗抑郁的作用。
  • HY-111419
    DSP-1053 Inhibitor
    DSP-1053是有效地 SERT (Ki=1.02 nM) 抑制剂,具有部分5-HT1A (Ki=5.05 nM) 激动剂作用。
  • HY-10792A
    Eplivanserin mixture Inhibitor 99.95%
    Eplivanserin mixture 是一种选择性的血清素再摄取抑制剂,是5-HT2A 受体的拮抗剂。化合物信息来自专利WO 2005/002578 A1。
  • HY-B1490
    Imipramine hydrochloride Inhibitor 99.89%
    Imipramine hydrochloride抑制血清素转运蛋白(serotonin),体内试验的IC50值为32 nM。
  • HY-B0161A
    Duloxetine hydrochloride Inhibitor 99.92%
    Duloxetine盐酸盐是5-羟色胺-去甲肾上腺素重吸收抑制剂(SNRI),Ki为 4.6 nM。
  • HY-B1287
    Citalopram hydrobromide Inhibitor >99.0%
    Citalopram盐酸盐是选择性的血清素再摄取抑制剂 (SSRI) 类的抗抑郁药, 已被FDA批准用于治疗抑郁症。
  • HY-14258A
    Escitalopram oxalate Inhibitor >98.0%
    Escitalopram oxalate ((S)-(+)Citalopram oxalate) 是选择性5羟色胺重吸收抑制剂(SSRI),Ki为0.89 nM。
  • HY-B0457
    Clomipramine hydrochloride Inhibitor 99.72%
    Clomipramine 盐酸盐是5-羟色胺转运体(SERT)、去甲肾上腺素转运体(NET)和多巴胺转运体(DAT)阻断剂,Ki 分别为0.14,54 和 3 nM。
  • HY-15414
    Vortioxetine Inhibitor 98.81%
    Vortioxetine 是 5-HT1A,5-HT1B,5-HT3A,5-HT7 受体 和 5-羟色胺转运体 (SERT) 的抑制剂,其 Ki 值分别为 15 nM,33 nM,3.7 nM,19 nM 和 1.6 nM。
  • HY-15414A
    Vortioxetine hydrobromide Inhibitor 99.54%
    Vortioxetine hydrobromide 是5-HT1A,5-HT1B,5-HT3A,5-HT7 受体 和5-羟色胺转运体 (SERT) 的抑制剂,其Ki值分别为 15 nM,33 nM,3.7 nM,19 nM 和 1.6 nM。
  • HY-B0196A
    Venlafaxine hydrochloride Inhibitor 99.87%
    Venlafaxine盐酸盐是5-羟色胺和去甲肾上腺素重吸收抑制剂(SNRI)。
  • HY-B0602A
    Desvenlafaxine succinate hydrate Inhibitor 99.76%
    Desvenlafaxine琥珀酸水合物5-羟色胺去甲肾上腺素再摄取抑制剂(SNRI类抗抑郁化合物)。
  • HY-14261
    Vilazodone Hydrochloride Inhibitor 99.94%
    Vilazodone Hydrochloride (EMD 68843 Hydrochloride) 是 5-羟色胺转运体 (SER) 的抑制剂和 5-HT1A 受体的部分激动剂。
  • HY-B0168A
    Milnacipran hydrochloride Inhibitor 99.40%
    Milnacipran是5-羟色胺-去甲肾上腺素重吸收抑制剂(SNRI),可用于纤维肌痛。
  • HY-12850A
    Dasotraline hydrochloride Inhibitor 99.60%
    Dasotraline hydrochloride (SEP-225289 hydrochloride) 是具有阻断多巴胺,去甲肾上腺素和三羟色胺转运蛋白的三重再摄取抑制剂,IC50值分别为4,6和11 nM。
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