2. Signaling Pathways
  3. Epigenetics
  4. YTHDF

YTHDF 

(YTH) domain-containing family proteins (YTHDF)

(YTH) domain-containing family proteins (YTHDFs) are a class of cytoplasmic m6A-binding proteins characterized by the vertebrate YTH domain, which enables them to regulate RNA fate extensively. The YTH domain serves as the basis for specific recognition of m6A-modified RNA. As the most studied "readers" of m6A, the YTHDF family includes YTHDF1, YTHDF2, and YTHDF3. YTHDF1 promotes RNA translation, while YTHDF2 facilitates RNA decay. YTHDF3 exhibits a dual function that depends on its binding partner. Upon entering the cytoplasm, m6A-modified mRNAs are initially bound by YTHDF3 or a YTHDF3-YTHDF1 complex, followed by recognition by YTHDF2, thereby directing the diverse fates of the targeted mRNA. The YTHDF family plays a significant role in mediating tumor proliferation, metastasis, metabolism, drug resistance, and immunity. Moreover, they possess potential as predictive and therapeutic biomarkers[1].

YTHDF 亚型特异性产品:

YTHDF Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-154919
    DC-Y13-27 Inhibitor 99.52%
    DC-Y13-27 是一种 DC-Y13 衍生物和 YTHDF2 抑制剂 (KD: 37.9 μM)。DC-Y13-27 抑制 YTHDF2、恢复 FOXO3 和 TIMP1 蛋白水平，并降低 MMP1/3/7/9 表达。DC-Y13-27 诱导焦亡 (Pyroptosis)、增加 IL-1β 分泌。DC-Y13-27 减轻椎间盘退变、增强结肠癌和黑色素瘤对放疗的响应。DC-Y13-27 对乳腺癌具有抗肿瘤活性。
    DC-Y13-27
  • HY-137341
    SK-3-91 Degrader 98.33%
    SK-3-91 是一种 PROTAC 类多激酶降解剂，可共同诱导最大数量的独特激酶 (超过 125 种独特激酶) 的降解。SK-3-91 通过泛素生物素化 (E-STUB) 途径诱导蛋白降解。SK-3-91 降解 YTHDF2。SK-3-91 抑制细胞增殖，诱导细胞形态变化。(Pink: TAE648 ligand (HY-169396); Blue: E3 ligase ligand (HY-131717); Black: Linker (HY-140819)。E3 连接酶配体和 Linker 可以组成偶联物 (HY-169397))。
    SK-3-91
  • HY-168610
    YTH-IN-1 Inhibitor 98.02%
    YTH-IN-1 (compound N-7) 是一种泛 YTH 结构域抑制剂，对人 YTHYTHDF1、YTHYTHDF2、YTHYTHDF3、YTHYTHDC1 和 YTHYTHDC2 的 IC50 值分别为 39 μM、34 μM、35 μM、48 μM 和 30 μM。
    YTH-IN-1
  • HY-173008
    YTHDF2-IN-1 Inhibitor
    YTHDF2-IN-1 (Compound CK-75) 是 YT521-B 同源域家族 2 YTHDF2 的抑制剂（Kd=26.2 μM），可阻断 YTHDF2 与 m6A RNA 之间的相互作用。YTHDF2-IN-1 可抑制 JAR 细胞的集落形成，在多种癌细胞中表现出抗增殖活性（IC50 为微摩尔水平），在 G0/G1 期阻滞细胞周期，诱导 K562 细胞凋亡 (apoptosis)。
    YTHDF2-IN-1
  • HY-RS15938
    YTHDF2 Human Pre-designed siRNA Set A Inhibitor
    YTHDF2 Human Pre-designed siRNA Set A 包括针对 YTHDF2 (Human) 基因的不同区域设计三对 siRNA，以及阴性对照、FAM 标记阴性对照和阳性对照。
    YTHDF2 Human Pre-designed siRNA Set A
    YTHDF2 Human Pre-designed siRNA Set A
  • HY-RS15939
    YTHDF3 Human Pre-designed siRNA Set A Inhibitor
    YTHDF3 Human Pre-designed siRNA Set A 包括针对 YTHDF3 (Human) 基因的不同区域设计三对 siRNA，以及阴性对照、FAM 标记阴性对照和阳性对照。
    YTHDF3 Human Pre-designed siRNA Set A
    YTHDF3 Human Pre-designed siRNA Set A
  • HY-RS15937
    YTHDF1 Human Pre-designed siRNA Set A Inhibitor
    YTHDF1 Human Pre-designed siRNA Set A 包括针对 YTHDF1 (Human) 基因的不同区域设计三对 siRNA，以及阴性对照、FAM 标记阴性对照和阳性对照。
    YTHDF1 Human Pre-designed siRNA Set A
    YTHDF1 Human Pre-designed siRNA Set A
YTHDF Isoform Comparison

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