2. PROTAC Metabolic Enzyme/Protease Apoptosis Cell Cycle/DNA Damage Epigenetics
  3. PROTACs Fat Mass and Obesity-associated Protein (FTO) Apoptosis Caspase PARP YTHDF
  4. PROTAC FTO degrader 1

PROTAC FTO degrader 1 是一种脂肪量和肥胖相关蛋白 (FTO) 的 PROTAC 降解剂。PROTAC FTO degrader 1 依赖于 VHL E3 连接酶和泛素-蛋白酶体系统选择性降解 FTO。PROTAC FTO degrader 1 可增加与核糖体生物发生相关的 mRNA 上的 m6A 修饰，并促进其由 YTHDF2 介导的降解。PROTAC FTO degrader 1 能够抑制癌细胞增殖并诱导凋亡 (apoptosis)。PROTAC FTO degrader 1 可用于癌症研究，如急性髓系白血病 (AML)。(结构：粉色：FTO 配体 (HY-175886)；蓝色：VHL 连接酶配体 (HY-112078)；黑色：连接子 (HY-W002042)；VHL 配体-Linker： (HY-139218))

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PROTAC FTO degrader 1

PROTAC FTO degrader 1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

PROTAC FTO degrader 1 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

查看 YTHDF 亚型特异性产品:

查看所有亚型
YTHDF1 YTHDF3 YTHDF2 YTHDC1 YTHDC2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC FTO degrader 1 is a Fat Mass and Obesity-associated Protein (FTO) PROTAC degrader. PROTAC FTO degrader 1 selectively degrades FTO depending on VHL E3 ligase and ubiquitin-proteasome system. PROTAC FTO degrader 1 can increase m6A modifications on mRNAs associated with ribosome biogenesis and promote their YTHDF2-mediated decay. PROTAC FTO degrader 1 can inhibit cancer cells proliferation and induce apoptosis. PROTAC FTO degrader 1 can be used for the research of cancer, such as acute myeloid leukemia (AML)[1]. (Structure Note: Pink: FTO ligand (HY-175886); Blue: VHL ligand (HY-112078); Black: linker (HY-W002042); VHL ligand-Linker: (HY-139218))

IC50 & Target[1]

VHL

 

PARP1

 

Caspase 3

 

YTHDF2

 

体外研究
(In Vitro)

PROTAC FTO degrader 1 (Compound FP54) (0.08-2.5 μM, 48 h) 在 NB4 和 MOLM-13 细胞中以剂量依赖性方式降解 FTO，最大降解率 >95%[1]。
PROTAC FTO degrader 1 抑制多种急性髓系白血病细胞系的增殖， IC50 值为 0.48-2.44 μM[1]。
PROTAC FTO degrader 1 (2-5 μM, 48 h) 显著诱导 MOLM-13 和 NB4 细胞凋亡[1]。
PROTAC FTO degrader 1 (5 μM) 促进 MOLM-13 细胞分化[1]。
PROTAC FTO degrader 1 (2 μM, 48 h) 提高 NB4 细胞中整体 mRNA 的 m6A 修饰水平[1]。
PROTAC FTO degrader 1 (2 μM, 48 h) 降低 MOLM-13 细胞中的多核糖体/80S 单核糖体比率，并抑制整体翻译[1]。
PROTAC FTO degrader 1 (2 μM) 在 MOLM-13 细胞中会使 YTHDF2 中富集核糖体生物发生相关 mRNA MRPL36 和 LYAR，降低其 mRNA 稳定性，并促进 YTHDF2 介导的降解[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC FTO degrader 1 相关抗体:

Apoptosis Analysis[1]

Cell Line: MOLM-13 and NB4 cells
Concentration: 2 and 5 μM
Incubation Time: 48 h
Result: Increased apoptotic cells.
Induced cleavage of caspase-3 and PARP1.
体内研究
(In Vivo)

PROTAC FTO degrader 1 (Compound FP54) (25 mg/kg，静脉注射，每周 3 次) 可延缓 MA9.3Ras/MOLM13/AML-0148 肿瘤小鼠中的疾病发作，并延长其生存期[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MA9.3Ras/ MOLM13/AML-0148 tumor mice models[1]
Dosage: 25 mg/kg
Administration: Intraperitoneally injection, 3 times a week
Result: Reduced AML cell engraftment in peripheral blood and bone marrow.
Decreased leukemia burden and delayed disease onset.
Prolonged survival.
Showed no obvious toxicity to mouse body weight, blood routine, or major organs.
分子量

1173.25

Formula

C59H75Cl2N9O10S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC FTO degrader 1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC FTO degrader 1PROTAC FTO degrader1PROTAC FTO degrader-1PROTACsFat Mass and Obesity-associated Protein (FTO)ApoptosisCaspasePARPYTHDFpoly ADP ribose polymerase (YTH) domain-containing family proteins (YTHDF)PROTACFTOYTHDF2AMLNB4MOLM-13,ApoptosisMA9.3RasMOLM13AML-0148Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
PROTAC FTO degrader 1
目录号：
HY-175885
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z