1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. PEPCK

PEPCK (磷酸烯醇丙酮酸羧激酶)

Phosphoenolpyruvate Carboxykinase

PEPCK (磷酸烯醇丙酮酸羧激酶) 是裂合酶家族中的一种酶,参与四种代谢过程: 糖异生、甘油异生、丝氨酸合成和氨基酸碳骨架的转化。PEPCK 是肝脏和肾脏糖异生的限速酶,也是 TCA 循环通量的关键调节因子。PEPCK 可以催化草酰乙酸转化为磷酸烯醇丙酮酸 (PEP) 和二氧化碳。PEPCK 有两种亚型: PEPCK1 (PEPCK-C) 和 PEPCK2 (PEPCK-M)。PEPCK1/PEPCK2 分布于胞质溶胶和线粒体中,并在许多癌症中过表达[1][2]

PEPCK (Phosphoenolpyruvate carboxykinase) is an enzyme in the lyase family used in four pathways: gluconeogenesis, glyceroneogenesis, the synthesis of serine, and the conversion of the carbon skeletons of amino acids. PEPCK is the rate-limiting enzyme of gluconeogenesis in the liver and kidney, and is also a key regulator of TCA cycle flux. PEPCK can catalyze oxaloacetate into phosphoenolpyruvate (PEP) and carbon dioxide. PEPCK has two isoforms: PEPCK1 (PEPCK-C) and PEPCK2 (PEPCK-M). PEPCK1/PEPCK2 is distributed in the cytosol and mitochondria, and is overexpressed in many cancers[1][2].

PEPCK 相关产品 (2):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-128923
    SKF-34288 hydrochloride Inhibitor
    SKF-34288 hydrochloride 是一种具有口服活性的磷酸烯醇丙酮酸羧激酶 (PEPCK) 抑制剂 (Ki: 2-9 μM)。SKF-34288 hydrochloride 通过抑制葡萄糖合成产生降血糖作用。SKF-34288 hydrochloride 抑制 Asn 代谢并导致氨基酸和酰胺的增加。
    SKF-34288 hydrochloride
  • HY-N3720
    Demethoxycapillarisin Inhibitor
    Demethoxycapillarisin (6-Demethoxycapillarisin) 通过激活 PI3K 通路抑制 PEPCK mRNA 水平 (IC50: 43 μM)。Demethoxycapillarisin 可降低葡萄糖的产生。