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SKF-34288 hydrochloride (Synonyms: 3-Mercaptopicolinic acid hydrochloride)

目录号: HY-128923 纯度: >95.0%
产品使用指南

SKF-34288 hydrochloride 是磷酸烯醇丙酮酸羧激酶 (PEPCK) 抑制剂。SKF-34288 hydrochloride 通过糖异生途径中 PEPCK 的特异性抑制来抑制葡萄糖合成,是一种有效的降血糖药。SKF-34288 hydrochloride 抑制 Asn 代谢并导致氨基酸和酰胺的增加。

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SKF-34288 hydrochloride Chemical Structure

SKF-34288 hydrochloride Chemical Structure

CAS No. : 320386-54-7

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Size Price Stock Quantity
10 mM * 1 mL in Water ¥1370 In-stock
1 mg ¥650 In-stock
5 mg ¥1700 In-stock
10 mg ¥3000 In-stock
100 mg Get quote

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Description

SKF-34288 hydrochloride (3-Mercaptopicolinic acid) is a phosphoenolpyruvate carboxykinase (PEPCK) inhibitor. SKF-34288 hydrochloride is a potent hypoglycemic agent via inhibition of glucose synthesis through the specific inhibition of PEPCK in the gluconeogenesis pathway[1]. SKF-34288 hydrochloride inhibits Asn metabolism and results in an increase in amino acids and amides[2].

IC50 & Target

IC50: PEPCK[1]

Molecular Weight

191.64

Formula

C₆H₆ClNO₂S

CAS No.

320386-54-7

SMILES

O=C(C1=NC=CC=C1S)O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (26.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2181 mL 26.0906 mL 52.1812 mL
5 mM 1.0436 mL 5.2181 mL 10.4362 mL
10 mM 0.5218 mL 2.6091 mL 5.2181 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。 -80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

References
  • 摩尔计算器

  • 稀释计算器

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Keywords:

SKF-342883-Mercaptopicolinic acidSKF34288SKF 34288OthersInhibitorinhibitorinhibit

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产品名称:
SKF-34288 hydrochloride
目录号:
HY-128923
需求量: