1. Signaling Pathways
  2. GPCR/G Protein
  3. Succinate Receptor 1

Succinate Receptor 1 (琥珀酸受体)

SUCNR1; GPR91

The succinate receptor (SUCNR1, also known as GPR91) is a G protein-coupled receptor that is closely related to the family of P2Y purinoreceptors. The Succinate receptor was identified as being activated by physiological levels of the Kreb's cycle intermediate succinate and other dicarboxylic acids such as maleate. It is expressed in a variety of tissues, including blood cells, adipose tissue, the liver, retina, and kidney. In these tissues, this receptor and its ligand succinate have recently emerged as novel mediators in local stress situations, including ischemia, hypoxia, toxicity, and hyperglycemia. Amongst others, the succinate receptor is involved in recruitment of immune cells to transplanted tissues. Moreover, it was shown to play a key role in the development of diabetic retinopathy. However, most prominently, the role of locally increased succinate levels and succinate receptor activation in the kidney, stimulating the systemic and local renin–angiotensin system, starts to unfold: the succinate receptor is a key mediator in the development of hypertension and possibly fibrosis in diabetes mellitus and metabolic syndrome.

Succinate Receptor 1 相关产品 (5):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-130246
    NF-56-EJ40 99.92%
    NF-56-EJ40 是一种有效,高亲和力和高度选择性的人 SUCNR1 (GPR91) 拮抗剂,IC50 为 25 nM,Ki 为 33.5 nM,对大鼠 SUCNR1 几乎没有活性。 NF-56-EJ40 对人源化大鼠 SUCNR1 具有高亲和力,Ki 值为 17.4 nM。
    NF-56-EJ40
  • HY-125791
    cis-Epoxysuccinic acid Agonist 99.00%
    cis-Epoxysuccinic acid 是 succinate receptor (SUCNR1/GPR91) 的激动剂。cis-Epoxysuccinic acid 抑制 cAMP 的水平,其 EC50 值为 2.7 µM。cis-Epoxysuccinic acid 可用于心血管系统的研究。
    cis-Epoxysuccinic acid
  • HY-126217
    hGPR91 antagonist 1 98.71%
    hGPR91 Antagonist 1 (Compound 4c) 是一种有效的 GPR91 拮抗剂,对于人 GPR91 的 IC50 为 7 nM。
    hGPR91 antagonist 1
  • HY-154946
    SUCNR1-IN-1 Inhibitor 99.33%
    SUCNR1-IN-1 (Compound 20) 是一种 SUCNR1 抑制剂 (IC50: 对 hSUCNR1 为 88 nM)。SUCNR1-IN-1 可用于类风湿关节炎、肝纤维化或肥胖的研究。
    SUCNR1-IN-1
  • HY-145919
    hGPR91 antagonist 3 98.82%
    hGPR91 Antagonist 3 (Compound 5g) 是一种有效的具有口服活性的 GPR91 拮抗剂,对于人 GPR91 和大鼠 GPR91 的 IC50 分别为 35 nM 和 135 nM。
    hGPR91 antagonist 3