2. GPCR/G Protein
  3. Succinate Receptor 1
  4. cis-Epoxysuccinic acid

cis-Epoxysuccinic acid 

目录号: HY-125791 纯度: 99.00%
COA 产品使用指南

摩尔计算器

cis-Epoxysuccinic acid 是 succinate receptor (SUCNR1/GPR91) 的激动剂。cis-Epoxysuccinic acid 抑制 cAMP 的水平，其 EC50 值为 2.7 µM。cis-Epoxysuccinic acid 可用于心血管系统的研究。

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cis-Epoxysuccinic acid Chemical Structure

cis-Epoxysuccinic acid Chemical Structure

CAS No. : 16533-72-5

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥385
In-stock
100 mg ￥350
In-stock
500 mg ￥630
In-stock
1 g   询价  
5 g   询价  

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Customer Review

cis-Epoxysuccinic acid 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

cis-Epoxysuccinic acid is a succinate receptor (SUCNR1/GPR91) agonist. cis-Epoxysuccinic acid inhibits cAMP levels with an EC50 value of 2.7 µM. cis-Epoxysuccinic acid can be used for the research of cardiovascular system[1].

体外研究
(In Vitro)

cis-Epoxysuccinic acid (1-100 μM; 10 min) affects cAMP levels of HEK293 cells[1].
cis-Epoxysuccinic acid (0.1 μM-100 mM; 1 h) agonists SUCNR1 pathways without affects succinate dehydrogenase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

cis-Epoxysuccinic acid 相关抗体:

Cell Viability Assay[1]

Cell Line: HEK293 cells
Concentration: 1, 10 and 100 μM
Incubation Time: 10 min
Result: Inhibited cAMP levels with an EC50 value of 2.7 µM.

Cell Viability Assay[1]

Cell Line: HEK293 cells
Concentration: 0.1 μM-100 mM
Incubation Time: 1 hour
Result: Induced the Gq pathway, recruited arrestin 3 and elicited [Ca2+]i mobilization with EC50 values of 42, 74 and 191 µM, respectively.
体内研究
(In Vivo)

cis-Epoxysuccinic acid (1 mg/kg; i.v. once) has an effect on the blood pressure of rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats[1]
Dosage: 1 mg/kg
Administration: Intravenous injection; 1 mg/kg once
Result: Showed in vivo activity and increased blood pressure after injection.
分子量

132.07

Formula

C4H4O5
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 250 mg/mL (1892.94 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 7.5717 mL 37.8587 mL 75.7174 mL
5 mM 1.5143 mL 7.5717 mL 15.1435 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.00%

COA (261 KB) HNMR (264 KB) RP-HPLC (250 KB) MS (183 KB)

产品使用指南 (1538 KB)
参考文献

cis-Epoxysuccinic acid 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 7.5717 mL 37.8587 mL 75.7174 mL 189.2935 mL
5 mM 1.5143 mL 7.5717 mL 15.1435 mL 37.8587 mL
10 mM 0.7572 mL 3.7859 mL 7.5717 mL 18.9294 mL
15 mM 0.5048 mL 2.5239 mL 5.0478 mL 12.6196 mL
20 mM 0.3786 mL 1.8929 mL 3.7859 mL 9.4647 mL
25 mM 0.3029 mL 1.5143 mL 3.0287 mL 7.5717 mL
30 mM 0.2524 mL 1.2620 mL 2.5239 mL 6.3098 mL
40 mM 0.1893 mL 0.9465 mL 1.8929 mL 4.7323 mL
50 mM 0.1514 mL 0.7572 mL 1.5143 mL 3.7859 mL
60 mM 0.1262 mL 0.6310 mL 1.2620 mL 3.1549 mL
80 mM 0.0946 mL 0.4732 mL 0.9465 mL 2.3662 mL
100 mM 0.0757 mL 0.3786 mL 0.7572 mL 1.8929 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cis-Epoxysuccinic acid16533-72-5Succinate Receptor 1SUCNR1GPR91cAMPblood pressureHEK29Gq pathwayarrestin 3Inhibitorinhibitorinhibit

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