Activin Receptor Type IIB 抗体 (YA6947)

Activin Receptor Type IIB Antibody (YA6947) is a non-conjugated IgG antibody, targeting Activin Receptor Type IIB, with a predicted molecular weight of 58 kDa (observed band size: 65 kDa). Activin Receptor Type IIB Antibody (YA6947) can be used for WB，IP experiment in human, mouse, rat background.

Activin Receptor Type IIB（ACVR2B）是一种跨膜丝氨酸/苏氨酸激酶（transmembrane serine/threonine kinase），通过与 I 型受体（ACVR1、ACVR1B 或 ACVR1C）形成 activin 受体复合物来转导信号。作为主要受体，ACVR2B 可结合 activin-A/INHBA、activin-B/INHBB 以及 inhibin-A/INHA-INHBA，在神经元分化与存活、毛囊发育、垂体 FSH 生成、伤口愈合、细胞外基质生成、免疫抑制和致癌等多种生理病理过程中发挥关键作用（by similar：在卵巢卵泡发育中可能具有旁分泌或自分泌功能）。被激活后，ACVR2B 磷酸化并激活 I 型受体，进而通过 SMAD2/SMAD3-SMAD4 复合物调控转录。其信号可被 SMAD7（通过 FKBP1A 招募）或 inhibin-B（通过 IGSF1 共受体结合）抑制。

Q13705

Predicted band size: 58 kDa; Observed band size: 65 kDa

Affinity Purified

Non-conjugated

Unmodified

Signal Transduction

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal, Recombinant

Rabbit

WB: 1:1000-1:5000; IP: 1:20-1:50

WB, IP

液体

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

A synthetic peptide of human Activin Receptor Type IIB/ACVR2B aa1-100.