Beclin 1 抗体 (YA6368)

Beclin 1 Antibody (YA6368) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Beclin 1.

Beclin 1 在自噬 (autophagy) 过程中发挥核心作用，并作为 PI3K 复合体的核心亚基参与磷脂酰肌醇 3-磷酸的形成。不同的复合体形式参与多种膜运输途径：PI3KC3-C1 参与自噬体 (autophagosome) 的起始，而 PI3KC3-C2 参与自噬体的成熟及内吞作用 (endocytosis)。此外，它还参与调节内吞运输降解过程，并在细胞分裂的 abscission 步骤中发挥作用（可能与 PI3KC3-C2 相关）。Beclin 1 对 PI3KC3-C2 复合体的形成至关重要，但对 PI3KC3-C1 并非必需。by similar: 它可能参与抗病毒宿主防御；线粒体定位的 Beclin-1-C 35 kDa 可促进细胞凋亡 (apoptosis)，诱导 BAX 的线粒体转位及促凋亡因子的释放；（微生物感染）可抵抗辛德毕斯病毒 (Sindbis virus) 神经毒株的感染。

Q14457

Predicted band size: 50 kDa

affinity purified.

Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells.

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse, Rat

IHC-P: 1:50-200; WB: 1:100-1000; IF: 1:50-200; IHC-F: 1:50-200

IHC-P, WB, IF-Tissue, IHC-F

液体

Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Recombinant human Beclin 1 protein aa 141-450/450