Cyclin H 抗体 (YA5224)

Cyclin H Antibody (YA5224) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Cyclin H.

Cyclin H 是 CDK7 的调节亚基，而 CDK7 是 CDK 激活激酶 (CAK) 复合物的催化亚基。CAK 通过苏氨酸磷酸化激活与细胞周期蛋白相关的激酶 CDK1、CDK2、CDK4 和 CDK6。当 CAK 与核心转录因子 IIH (core-TFIIH) 结合时，可通过 RNA 聚合酶 II 大亚基 (POLR2A) 的 C 端重复结构域 (CTD) 的丝氨酸磷酸化来激活 RNA 聚合酶 II，从而使其从启动子脱离并促进转录延伸。Cyclin H 参与细胞周期调控和 RNA 聚合酶 II 介导的转录过程，其表达和活性在整个细胞周期中保持恒定。

P51946

Observed band size: 38 kDa; Observed band size: 38 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:1000; IP: 1:20

WB, IP

液体

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2b

Purified recombinant human Cyclin H protein fragments expressed in E.coli.