PAR1 抗体 (YA5005)

PAR1 Antibody (YA5005) is a mouse-derived and non-conjugated monoclonal antibody, targeting to PAR1. It can be applicated for WB, ELISA assays, in the background of human.

F2R 是一种高亲和力受体，能够结合激活的 thrombin，从而触发细胞内钙库的钙离子释放。该受体通过 PTX-insensitive G 蛋白介导信号通路，激活 phospholipase C，产生 1D-myo-inositol 1,4,5-trisphosphate (InsP3)，后者结合 InsP3 受体导致钙离子释放。在 astrocytes 中，释放到胞质中的钙离子通过 BEST1 促进 L-glutamate 释放到突触间隙，靶向神经元突触后 GRIN2A/NMDAR 受体以调节突触可塑性。此外，F2R 可能在血小板激活和血管发育中发挥作用，并在心脏成纤维细胞和脐静脉内皮细胞中介导由 coagulation factor Xa (F10) 触发的促炎细胞因子（如 MCP-1/CCL2 和 IL6）的上调。

P25116

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; ELISA: 1:10000

WB, ELISA

液体

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of PAR1 expressed in E. Coli.