1. Gene
  2. BCL2L10 - BCL2 like 10 Gene

BCL2L10 - BCL2 like 10 Gene

中文名称:BCL2 样 10

种属: Homo sapiens

同用名: Boo; Diva; BCL-B; bcl2-L-10

基因 ID: 10017 | 基因类型: protein coding

关于 BCL2L10

Cytogenetic location: 15q21.2 Genomic coordinates (GRCh38): 15:52,109,263-52,112,775 (from NCBI)

This gene has 2 transcripts (splice variants), 132 orthologues and 8 paralogues. Broad expression in skin (RPKM 2.0), kidney (RPKM 1.9) and 15 other tissues.


该基因编码的蛋白质属于 Bcl-2 蛋白家族。 Bcl-2 家族成员形成异二聚体或同二聚体,并作为参与多种细胞活动的抗或促凋亡调节剂。该基因编码的蛋白质包含保守的 BH4、BH1 和 BH2 结构域。该蛋白可以与 Bcl-2 蛋白家族的其他成员相互作用,包括 BCL2、BCL2L1/BCL-X (L) 和 Bax。该基因的过表达已被证明可能通过阻止细胞色素 C 从线粒体中释放来抑制细胞凋亡,从而激活 caspase-3 激活。发现该蛋白质的小鼠对应物与 Apaf1 相互作用并与 Caspase 9 形成蛋白质复合物,这表明该蛋白质参与 APAF1 和 Caspase 9 相关的细胞凋亡途径。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 Family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of Bcl-2 protein family including BCL2, BCL2L1/BCL-X(L), and Bax. Overexpression of this gene has been shown to suppress cell Apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and Caspase 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]

BCL2L10 基因产物(2)

mRNA Protein Name
NM_001306168.1 NP_001293097.1 bcl-2-like protein 10 isoform 1
NM_020396.4 NP_065129.1 bcl-2-like protein 10 isoform 2

BCL2L10 蛋白结构


Bcl-2: Apoptosis regulator proteins, Bcl-2 family (49 - 163)

  • 0
  • 100
  • 204 a.a.
蛋白主名 其他名称

bcl-2-like protein 10

BCL2-like 10 (apoptosis facilitator)

anti-apoptotic protein Boo

anti-apoptotic protein NrH

apoptosis regulator Bcl-B

death inducer binding to vBcl-2 and Apaf-1


种属 基因名 来源 基因 ID
Macaca mulatta BCL2L10 VGNC VGNC:84313
Mus musculus BCL2L10 MGD MGI:1330841
Rattus norvegicus BCL2L10 RGD RGD:621015